ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- CAS No.
- 10129-56-3
- Chemical Name:
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- Synonyms
- PETCM;APOPTOSIS ACTIVATOR I;α-(Trichloromethyl)-4-pyridineethanol;a-(Trichloromethyl)-4-pyridineethanol;4-Pyridineethanol, α-(trichloromethyl)-;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
- CBNumber:
- CB8197667
- Molecular Formula:
- C8H8Cl3NO
- Molecular Weight:
- 240.51
- MDL Number:
- MFCD00177920
- MOL File:
- 10129-56-3.mol
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1758 | PETCM ≥99%(HPLC) | 10129-56-3 | 50 | $189 | 2021-12-16 | Buy |
| TRC | P999025 | PETCM | 10129-56-3 | 1mg | $40 | 2021-12-16 | Buy |
| Usbiological | 256215 | PETCM | 10129-56-3 | 50mg | $475 | 2021-12-16 | Buy |
| ApexBio Technology | A4420 | PETCM | 10129-56-3 | 50mg | $329 | 2021-12-16 | Buy |
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties,Uses,Production
Uses
PETCM is a caspace-3 activator in cell extracts.
Definition
ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.
Biological Activity
petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].
storage
Room temperature
References
[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
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