N-Boc-1-aminocyclobutanecarboxylic acid
- CAS No.
- 120728-10-1
- Chemical Name:
- N-Boc-1-aminocyclobutanecarboxylic acid
- Synonyms
- BOC-ACBC-OH;BOC-AC4C-OH;BOC-1, 1-ACCB;BOC-CYCLOVALINE;Boc-1-Aminocyclobutanecarboxylic acid;Boc-1-aminocyclobutane-1-carboxylicaci;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID;N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID;BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID;BOC-1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID
- CBNumber:
- CB7110182
- Molecular Formula:
- C10H17NO4
- Molecular Weight:
- 215.25
- MDL Number:
- MFCD02682623
- MOL File:
- 120728-10-1.mol
- MSDS File:
- SDS
Melting point | 129-133 °C(lit.) |
---|---|
Boiling point | 362.1±21.0 °C(Predicted) |
Density | 1.18±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
pka | 4.14±0.20(Predicted) |
form | Powder |
color | White to light brown |
BRN | 7994003 |
InChI | InChI=1S/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13) |
InChIKey | ROVVUKFHORPDSM-UHFFFAOYSA-N |
SMILES | C1(NC(OC(C)(C)C)=O)(C(O)=O)CCC1 |
CAS DataBase Reference | 120728-10-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H335-H302-H319 | |||||||||
Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
Safety Statements | 36 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29242990 | |||||||||
NFPA 704 |
|
N-Boc-1-aminocyclobutanecarboxylic acid price More Price(41)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 630802 | N-Boc-1-aminocyclobutane carboxylic acid 97% | 120728-10-1 | 1g | $98.9 | 2023-06-20 | Buy |
Sigma-Aldrich | 630802 | N-Boc-1-aminocyclobutane carboxylic acid 97% | 120728-10-1 | 5g | $419 | 2023-06-20 | Buy |
TCI Chemical | B6086 | N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid | 120728-10-1 | 1G | $26 | 2024-03-01 | Buy |
TCI Chemical | B6086 | N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid | 120728-10-1 | 5G | $79 | 2024-03-01 | Buy |
Alfa Aesar | H62888 | 1-(Boc-amino)cyclobutanecarboxylic acid, 97% | 120728-10-1 | 5g | $179 | 2021-12-16 | Buy |
N-Boc-1-aminocyclobutanecarboxylic acid Chemical Properties,Uses,Production
Uses
Boc-1-aminocyclobutane-1-carboxylic Acid is used in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. It is also used to prepare alkyl-oxo-aryl amides as novel antagonists of TRPA1 receptor.
Synthesis
Under stirring, add 1-aminocyclobutylcarboxylic acid (500mg, 4.34mmol) to 10mL of 0.5M sodium hydroxide solution, and add 10mL of 1,4-dioxane and di-tert-butyl dicarbonate (1.42g, 6.51 mmol), react for 15 hours. Extract with diethyl ether (20 mL × 2), add hydrochloric acid dropwise until the pH of the aqueous phase is 4, and extract with ethyl acetate (30 mL × 3). The organic phases were then combined, washed with saturated sodium chloride solution (20mL×2), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the product N-Boc-1-aminocyclobutanecarboxylic acid (750mg, white solid), yield:80.6%.
![24424-99-5](/CAS/GIF/24424-99-5.gif)
![22264-50-2](/CAS/GIF/22264-50-2.gif)
![120728-10-1](/CAS/GIF/120728-10-1.gif)
N-Boc-1-aminocyclobutanecarboxylic acid Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9257 | 58 |
Shanghai Famo Biotech Co Ltd | +8618550473860 | mayan@famobiotech.com | China | 514 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
View Lastest Price from N-Boc-1-aminocyclobutanecarboxylic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2022-10-01 | N-Boc-1-aminocyclobutanecarboxylic acid
120728-10-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
![]() |
2019-08-06 | N-Boc-1-aminocyclobutanecarboxylic acid
120728-10-1
|
US $1.00 / KG | 1KG | 98% | 10KG | Career Henan Chemical Co |
-
- N-Boc-1-aminocyclobutanecarboxylic acid
120728-10-1
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- N-Boc-1-aminocyclobutanecarboxylic acid
120728-10-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co