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NORBUPRENORPHINE

CAS No.
78715-23-8
Chemical Name:
NORBUPRENORPHINE
Synonyms
NORBUPRENORPHINE;N-Desalkylbuprenorphin;N-Dealkylbuprenorphine;Norbuprenorphine (CRM);Toremifene Impurity 19;N-Desalkylbuprenorphine;Buprenorphine Impurity B;Norbuprenorphine solution;N-De(cyclopropylmethyl)buprenorphine;N-Des(cyclopropylmethyl)buprenorphine
CBNumber:
CB7121849
Molecular Formula:
C25H35NO4
Molecular Weight:
413.55
MDL Number:
MFCD00190626
MOL File:
78715-23-8.mol
Last updated:2023-06-08 09:02:16

NORBUPRENORPHINE Properties

Melting point 221-224°C
Boiling point 562.7±50.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
Flash point 9℃
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 9.14±0.60(Predicted)
form A neat solid
FDA UNII 7E53B4O073

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  16-36/37-45-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
NFPA 704
0
3 0

NORBUPRENORPHINE Chemical Properties,Uses,Production

Description

Norbuprenorphine (CRM) (Item No. 20127) is a certified reference material categorized as an opioid. It is a major active metabolite of buprenorphine (Item Nos. 14025 | ISO60178). This product is intended for research and forensic applications.

Chemical Properties

Light Brown Solid

Uses

A metabolite of Buprenorphine

Definition

ChEBI: Norbuprenorphine is a member of phenanthrenes.

NORBUPRENORPHINE Preparation Products And Raw materials

Raw materials

Preparation Products

(aS,5a,7a)-a-(1,1-Dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-6,14-ethenomorphinan-7-methanol N-De(cyclopropylmethyl)buprenorphine N-Dealkylbuprenorphine N-Desalkylbuprenorphin 6,14-Ethenomorphinan-7-methanol, .alpha.-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-.alpha.-methyl-, (.alpha.S,5.alpha.,7.alpha.)- N-Desalkylbuprenorphine (αS)-α-tert-Butyl-4,5α-epoxy-3-hydroxy-6-methoxy-α-methyl-6β,14-ethanomorphinan-7α-methanol N-Des(cyclopropylmethyl)buprenorphine NORBUPRENORPHINE (αS,5α,7α)-α-(1,1-DiMethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-Methoxy-α-Methyl-6,14-ethenoMorphinan-7-Methanol Norbuprenorphine (1.0 Mg/ML in Methanol) Norbuprenorphine solution Norbuprenorphine (CRM) 6,14-Ethenomorphinan-7-methanol, α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (αS,5α,7α)- (2S)-2-(4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol (norbuprenorphine), Buprenorphine Hydrochloride Impurity B Buprenorphine Impurity B Buprenorphine Hydrochloride EP Impurity B Toremifene Impurity 19 78715-23-8 C25H35NO4 Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals