ChemicalBook >> CAS DataBase List >>(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE structure

CAS No.: 189028-95-3

Chemical Name:: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

Synonyms: (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one;ZT-5;idin-2-one;Ezetimibe-003;Ezetimibe INT A;(S)-3-((S)-5-(4-FL;-5-(4-Fluorophenyl);-5-hydroxypentanoyl);)-5-hydroxypentanoyL;Ezetimibe Impurity 45

CBNumber:: CB71473325

Molecular Formula:: C20H20FNO4

Molecular Weight:: 357.38

MDL Number:: MFCD13194798

MOL File:: 189028-95-3.mol

MSDS File:: SDS

Last updated:2024-04-18 11:29:28

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Properties

Boiling point	572.7±50.0 °C(Predicted)
Density	1.297
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
pka	14.17±0.20(Predicted)
color	White to Off-White

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F595465	3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one	189028-95-3	500mg	$135	2021-12-16	Buy
TRC	F595465	3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one	189028-95-3	5g	$1070	2021-12-16	Buy
American Custom Chemicals Corporation	CCH0038549	2-OXAZOLIDINONE, 3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXY-1-OXOPENTYL]-4-PHENYL-, (4S)- 95.00%	189028-95-3	10G	$1334.03	2021-12-16	Buy
AK Scientific	Y6621	(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one	189028-95-3	1g	$18	2021-12-16	Buy
American Custom Chemicals Corporation	CCH0038549	2-OXAZOLIDINONE, 3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXY-1-OXOPENTYL]-4-PHENYL-, (4S)- 95.00%	189028-95-3	5G	$255.15	2021-12-16	Buy

Product number	Packaging	Price	Buy
F595465	500mg	$135	Buy
F595465	5g	$1070	Buy
CCH0038549	10G	$1334.03	Buy
Y6621	1g	$18	Buy
CCH0038549	5G	$255.15	Buy

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Chemical Properties,Uses,Production

Description

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

Chemical Properties

Solid

Uses

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

References

http://www.cphi-online.com/ezetimibe-intermediate-4s3-prod587443.html
https://en.wikipedia.org/wiki/2-Oxazolidone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE synthesis

Synthesis of (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE from (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Suppliers

Global( 289)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	+86-021-68187180-811 +86-13681683526	lchen@syncozymes.com	China	188	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58

Supplier	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
career henan chemical co	58

(4S)- 3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-pheny-1,3-oxazolidin-2-one : Biosynthesis, Optimization of biosynthesis conditions And Influencing factors Studies
The (4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-pheny-1,3-oxazolidin-2-one,?is an chiral intermediate in the synthes....
Jan 18，2023

View Lastest Price from (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-01-31	Ezetimibe INT A 189028-95-3	US $0.00 / Kg/Drum	1Kg/Drum	99%	5000KG	Hebei Mojin Biotechnology Co., Ltd
2022-10-01	(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-12-22	(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3	US $10.00 / g	1KG	98%	500ton/Month	Qiuxian Baitai New Material Co., LTD

Ezetimibe INT A
189028-95-3
US $0.00 / Kg/Drum
99%
Hebei Mojin Biotechnology Co., Ltd

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
189028-95-3
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
189028-95-3
US $10.00 / g
98%
Qiuxian Baitai New Material Co., LTD

189028-95-3((4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE)Related Search:

5-(4-FLUOROPHENYL)VALERIC ACID Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate (4S,5R)-5-[3,5-bis(triflu... 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone (3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid

3-O-Acetyl Ezetimibe ent-EzetiMibe EzetiMibe LactaM Cleaved Alcohol Dextran 4-(4-Fluorobenzoyl)butyric acid

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Ezetimibe 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Flupirtine maleate PD 0332991 HCl

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxo-pentyl]-4-phenyl-2-Oxazolidinone EzetiMibe InterMediates 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- 2-Oxazolidinone Ezetimibe INT A ZT-5 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl- (4S)-3-[(5R)-5-(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-pheny-1,3-oxzolidin-2-One 2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- -5-(4-Fluorophenyl) -5-hydroxypentanoyl) (S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-2-oxazolidinone Ezetimibe Impurity 45 Ezetimibe-003 Ezetimibe Impurity 51 3-[5-(4-fluoro- phenyl)-5-hydroxy- pentanoyl]-5-phenyl- oxazolidin-2-one 3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one (S)-3-((S)-5-(4-FL idin-2-one )-5-hydroxypentanoyL (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONEENYL-2-OXAZOLIDINONE (4S)-3-[(5S)-5-(3-fluorophenyl)-5- hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL... (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one Ezetimibe Impuriry 51 Ezetimibe intermediate D 189028-95-3 (4S)-3-[(5S)-5-(3-FLUOROPHENYL)-5- 3-[(5S)-5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4(S)-phenyl-2-oxazolidinone (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxyvaleryl] -4-phenyl-1,3-oxyazacyclopentane-2-one (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxypentanoyl] -4-phenyl-1,3-oxazole-2-one 189028-95-3 Ezetimibe Ezetimibe intermediates 189028-95-3