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Ginsenoside Rb1

Ginsenoside Rb1 structure

CAS No.: 41753-43-9

Chemical Name:: Ginsenoside Rb1

Synonyms: GYPENOSIDE;GINSENOSIDE GINSENOSIDE-RB1;(3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside;NSC 310103;Gypenoside I;arasaponine1;gynosaponinc;Gypenoside Ⅲ;gypenosideiii;panaxsaponine

CBNumber:: CB7237661

Molecular Formula:: C54H92O23

Molecular Weight:: 1109.29

MDL Number:: MFCD00133367

MOL File:: 41753-43-9.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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Ginsenoside Rb1 Properties

Melting point	197.5°C
Boiling point	766.35°C (rough estimate)
Density	1.0971 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	2-8°C
solubility	methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow
pka	12.85±0.70(Predicted)
form	Solid
color	Off-White to Pale Beige
Stability	Hygroscopic
InChIKey	GZYPWOGIYAIIPV-VOKNSFSUNA-N
LogP	2.900 (est)
CAS DataBase Reference	41753-43-9(CAS DataBase Reference)
FDA UNII	7413S0WMH6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Xn,Xi,T,F

Risk Statements

20/21/22-39/23/24/25-23/24/25-11

Safety Statements

26-36-45-36/37-16-7

WGK Germany

RTECS

LZ5856000

HS Code

29389090

Toxicity

oms-rat-ipr 50 mg/kg CPBTAL 24,2400,76

NFPA 704

	0
3		0

Ginsenoside Rb1 price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G0777	Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root triterpenoid saponin	41753-43-9	5mg	$652	2024-03-01	Buy
Sigma-Aldrich	00170580	Ginsenoside Rb1 primary pharmaceutical reference standard	41753-43-9	10mg	$766	2024-03-01	Buy
Cayman Chemical	15319	Ginsenoside Rb1 ≥98%	41753-43-9	5mg	$93	2024-03-01	Buy
Cayman Chemical	15319	Ginsenoside Rb1 ≥98%	41753-43-9	10mg	$176	2024-03-01	Buy
Sigma-Aldrich	Y0001347	Ginsenoside Rb1 European Pharmacopoeia (EP) Reference Standard	41753-43-9	y0001347	$220	2024-03-01	Buy

Product number	Packaging	Price	Buy
G0777	5mg	$652	Buy
00170580	10mg	$766	Buy
15319	5mg	$93	Buy
15319	10mg	$176	Buy
Y0001347	y0001347	$220	Buy

Ginsenoside Rb1 Chemical Properties,Uses,Production

Description

Ginsenoside Rb1, a glycosylated PPD type ginsenoside with two sugars linked to C-3 and two sugars linked to C-20, is the major active constituent of American ginseng. Studies have demonstrated the anti-aging effects of ginsenoside Rb1 at both animal and cell levels. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (20GPPD) is the major ingredient of ginsenoside Rb1, which has been shown to increase HAS2 expression by phosphorylating ERK and AKT signaling in human keratinocytes in a dose-dependent manner in vitro.

Uses

A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.

Uses

Reference standard in the analysis of herbal medicinal products.

Definition

ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.

benefits

Ginsenoside Rb1 (G-Rb1) is a tetracyclic triterpenoid mainly obtained from the roots or stems of Panax notoginseng and ginseng by extraction and purification. It is one of the main bioactive compounds of ginseng with minimal toxicity and neurotrophic and neuroprotective effects on brain injury. G-Rb1 promotes hippocampal nerve regeneration, enhances learning and memory, and has anti-aging and anti-fatigue effects. In addition, it activates antioxidants, stimulates the immune system, has anti-apoptotic activity, and maintains cell adenosine triphosphate (ATP) levels[1].

General Description

Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.

Biochem/physiol Actions

Triterpene saponin found in ginseng.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes.

target

p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor

References

[1] Shan Wen. “Ginsenoside Rb1 improves energy metabolism after spinal cord injury.” Neural Regeneration Research 18 6 (2023): 1332–1338.

Ginsenoside Rb1 Preparation Products And Raw materials

Raw materials

Preparation Products

Ginsenoside Rb1 Suppliers

Global( 396)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-18791163155 +86-13119157289	13119157289@163.com	China	2973	58
Xi'an ZB Biotech Co.,Ltd	+8618591943808	sales01@xazbbio.com	China	815	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1249	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20287	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9210	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55

Supplier	Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Xi'an ZB Biotech Co.,Ltd	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Nanjing Finetech Chemical Co., Ltd.	55

View Lastest Price from Ginsenoside Rb1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-26	Ginsenoside Rb1 41753-43-9	US $0.00 / kg	0.1kg	50%-98% HPLC	100kg	Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
2024-11-26	Ginsenoside Rb1 41753-43-9	US $0.00 / MG	20MG	>95% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2024-11-26	Ginsenoside Rb1 41753-43-9	US $0.00 / MG	20MG	>95% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.

Ginsenoside Rb1
41753-43-9
US $0.00 / kg
50%-98% HPLC
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Ginsenoside Rb1
41753-43-9
US $0.00 / MG
>95% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Ginsenoside Rb1
41753-43-9
US $0.00 / MG
>95% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Ginsenoside Rb1 Spectrum

Ginsenoside Rb1(41753-43-9)MS

41753-43-9(Ginsenoside Rb1 )Related Search:

Ginsenoside Rg2 TRIBULOSIDE GINSENOSIDE RE Ginsenoside Rg1 Ginsenoside Re

Ginsenoside Rh2 GinsenosideRo 20(R)-Ginsenoside Rg3 Ginsenoside Rd Ginsenoside Rb3 (CAS#68403-26-8),GINSENOSIDE RB3

GINSENOSIDE RB2,GINSENOSIDE Rb2 hplc,GINSENOSIDE RB2 WITH HPLC Panaxadiol Panaxatriol Ginsenoside Rg3 Ginsenoside-Rg5

Ginsenoside Rh1 Ginsenoside Rk3 GINSENOSIDEF1

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GINSENOSIDE RB1 GINSENOSIDE RBL 2-O-beta-glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside Ginsenoside Rb1 std. ginsenoside-rb1from panax quinquefolium (american ginseng)root Ginsenoside Rb1 (CAS# 41753-43-9) GinsenosideRB1,SanchinosideE1 GINSENOSIDE Rb1 hplc Gensenoside Rb1 GINSENOSIDE RB1 WITH HPLC glucopyranosyl-β-D-glucopyranosyl)oxy]-12- hydroxydammar-24-en-3-yl2-O-β-D-glucopyra Notoginsenoside Rb1 Panaxoside Rb1 β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D- Gypenoside I hydroxydammar-24-en-3-yl O-6-deoxy-α-L- mannopyranosyl-(1→6)-O-[β-D- (20S)-3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol [20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl]2-O-β-D-glucopyranosyl-β-D-glucopyranoside 3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol ginsenoside-Rb1 standard (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-beta-d-glucopyranosid arasaponine1 glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl- gynosaponinc gypenosideiii panaxsaponine pseudoginsenosided SANCHINOSIDE E1 Ginsenoside Rb1 ,98% (3β,12β)-20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydaMMar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside Purity of Ginsenoside Rg1 NSC 310103 Sanchinoside Rb1 Ginsenoside Rb1, froM Panax ginseng Ginsenoside Rb1 (saponin of panax ginseng) Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root 2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside (3beta,12beta)-20-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-O-beta-D-glucopyranosyl-beta-D-glucopyranosi Ginsenoside Rb1 41753-43-9 Ginsenoside Rb1, 98%, from Panax ginseng C. A. Mey. Ginsenoside Rb1 CRS Ginsenoside Rb1 RS Gypenoside Ⅲ β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl- (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3, GINSENOSIDE GINSENOSIDE-RB1 (3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside GYPENOSIDE (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Rb1 Ginsenoside Rb1 Ginsenoside Rb1-RM Ginsenoside Rb1(AS) Ginsenoside Rb1(P) 41753-43-9 41753-53-9