CAY10581

CAY10581 structure

CAS No.: 1018340-07-2

Chemical Name:: CAY10581

Synonyms: CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-

CBNumber:: CB72590430

Molecular Formula:: C22H21NO4

Molecular Weight:: 363.41

MDL Number:: MFCD18428034

MOL File:: 1018340-07-2.mol

Last updated:2023-04-23 13:52:06

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CAY10581 Properties

Boiling point	548.8±50.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
solubility	DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form	A crystalline solid
pka	12.53±0.60(Predicted)

CAY10581 price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16838	CAY10581 ≥97%	1018340-07-2	1mg	$37	2024-03-01	Buy
Cayman Chemical	16838	CAY10581 ≥97%	1018340-07-2	5mg	$161	2024-03-01	Buy
Cayman Chemical	16838	CAY10581 ≥97%	1018340-07-2	10mg	$283	2024-03-01	Buy
Cayman Chemical	16838	CAY10581 ≥97%	1018340-07-2	25mg	$618	2024-03-01	Buy

Product number	Packaging	Price	Buy
16838	1mg	$37	Buy
16838	5mg	$161	Buy
16838	10mg	$283	Buy
16838	25mg	$618	Buy

CAY10581 Chemical Properties,Uses,Production

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC₅₀ = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.

Uses

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor.

CAY10581 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10581 Suppliers

Global( 26)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44808	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24648	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58

Supplier	Advantage
Alfa Chemistry	58
Aladdin Scientific	58
Shanghai Hongye Biotechnology Co. Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Energy Chemical	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

CAY10581 CAY10581 Exclusive 2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel- 1018340-07-2