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ChemicalBook >> CAY10581

CAY10581

CAY10581 price.
  • $37 - $618
  • Product name: CAY10581
  • CAS: 1018340-07-2
  • MF: C22H21NO4
  • MW: 363.41
  • EINECS:
  • MDL Number:MFCD18428034
  • Synonyms:CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-
4 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerCayman Chemical
  • Product number16838
  • Product descriptionCAY10581 ≥97%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16838
  • Product descriptionCAY10581 ≥97%
  • Packaging5mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16838
  • Product descriptionCAY10581 ≥97%
  • Packaging10mg
  • Price$283
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16838
  • Product descriptionCAY10581 ≥97%
  • Packaging25mg
  • Price$618
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 16838 CAY10581 ≥97% 1mg $37 2024-03-01 Buy
Cayman Chemical 16838 CAY10581 ≥97% 5mg $161 2024-03-01 Buy
Cayman Chemical 16838 CAY10581 ≥97% 10mg $283 2024-03-01 Buy
Cayman Chemical 16838 CAY10581 ≥97% 25mg $618 2024-03-01 Buy

Properties

Boiling point :548.8±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
solubility :DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form :A crystalline solid
pka :12.53±0.60(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.