Description
U-46619 is the consensus stable analog of prostaglandin H2/thromboxane A2 (PGH2/TXA2) and has been used as a TXA2 agonist in pharmacologic studies for several decades.1 There have been several hypotheses put forward by scientists studying ω-3 fatty acids stipulating that the agonist activity of TXA3 was substantially different than that of TXA2.2 However, no stable analogs of TXA3 were available to test these theories. Δ17-U-46619 is the first direct, stable analog of TXA3 ever synthesized. There are no published reports on its activity to date.
References
1. Bundy, G.L. The synthesis of prostaglandin endoperoxide analogs Tetrahedron Lett. 24,1957-1960(1975).
2. Parent, C.A., Lagarde, M., Venton, D.L., et al. Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes J. Biol. Chem. 267,6541-6547(1992).
