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ChemicalBook >> CAS DataBase List >>3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole

3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole

3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Structure
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole structure
CAS No.
1052174-67-0
Chemical Name:
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole
Synonyms
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole;1-[Difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole;1,2-Benziodoxole, 1-[difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl-;1-(Difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1lambda3-benzo[d][1,2]iodaoxole;1-(difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1l3-benzo[d][1,2]iodaoxole
CBNumber:
CB72709373
Molecular Formula:
C16H15F2IO3S
Molecular Weight:
452.25
MDL Number:
MFCD28015843
MOL File:
1052174-67-0.mol
Last updated:2024-01-23 10:47:02
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3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Properties

Melting point 89-90 °C

SAFETY

Risk and Safety Statements

HS Code  29350090

3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Chemical Properties,Uses,Production

Description

3,3-Dimethyl-1-[difluoro(phenylsul fonyl)methyl]-1,2-benziodoxole is a novel electrophilic difluoromethylation reagent prepared from TMSCF2SO2Ph, which can efficiently transfer the PhSO2CF2 moiety to nucleophiles such as thiols under mild reaction conditions. Copper(II)-catalyzed decarboxylative difluoro(phenylsulfonyl)methylation of α,β- or β,γ-unsaturated carboxylic acids with this reagent can afford vinylic and allylic difluoromethylation products.

Reactions

(1) Difluoromethylation of thiols.
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole
(2) Difluoromethylation of β,γ-unsaturated carboxylic acids.
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole
(3) Difluoromethylation of α,β-unsaturated carboxylic acids.
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole

References

[1] WEI ZHANG; Jinbo H; Jieming Zhu. Electrophilic (phenylsulfonyl)difluoromethylation of thiols with a hypervalent iodine(III)–CF2SO2Ph reagent[J]. Tetrahedron Letters, 2008. DOI:10.1016/j.tetlet.2008.06.064.
[2] ZHENGBIAO HE. Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations?[J]. Angewandte Chemie International Edition, 2012, 51 16: 3944-3947. DOI:10.1002/anie.201200140.
[3] DR. ZHENGBIAO HE. Copper-Catalyzed Difluoromethylation of β,γ-Unsaturated Carboxylic Acids: An Efficient Allylic Difluoromethylation?[J]. Angewandte Chemie International Edition, 2012, 51 46: 11545-11547. DOI:10.1002/anie.201206556.

3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole synthesis

175786-58-0
536975-50-5
1052174-67-0
Synthesis of 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole from 1,2-Benziodoxole, 1-(acetyloxy)-1,3-dihydro-3,3-dimethyl and [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane

3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Preparation Products And Raw materials

Raw materials

Preparation Products

3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-55982848 +86-15093356674 sales@coreychem.com China 29901 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39916 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9821 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94735 76
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6943 65
Greenherbs Science and Technology Development Co., Ltd. 010-61136123 pub02@greenherbs.com.cn China 4049 58
JinJin Le Chemical Co., Ltd 10106090 jjlchem2@163.com China 9986 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 56057 58
TCI (Shanghai) Chemical Trading Co., Ltd. 021-021-61109150 sales@tcisct.com China 31163 58
Ningbo Chemrio Chemtech Co,.Ltd. 0574-27891269 18667892864 frank.xiaodong@chemriotech.com China 3583 58
Supplier Advantage
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
changzhou huayang technology co., ltd 		58
J & K SCIENTIFIC LTD. 76
Daicel Chiral Technologies (China)CO.,LTD 65
Greenherbs Science and Technology Development Co., Ltd. 58
JinJin Le Chemical Co., Ltd 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
TCI (Shanghai) Chemical Trading Co., Ltd. 58
Ningbo Chemrio Chemtech Co,.Ltd. 58

View Lastest Price from 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole pictures 2019-07-06 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole
1052174-67-0
 US $1.00 / kg 1 g 99% 100KG Career Henan Chemical Co
3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole 1-(difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1l3-benzo[d][1,2]iodaoxole 1-[Difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole 1,2-Benziodoxole, 1-[difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl- 1-(Difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1lambda3-benzo[d][1,2]iodaoxole 1052174-67-0