Luotonine A
- CAS No.
- 205989-12-4
- Chemical Name:
- Luotonine A
- Synonyms
- Luotonine A;LUMDXNLBIYLTER-UHFFFAOYSA-N;Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one
- CBNumber:
- CB72709601
- Molecular Formula:
- C18H11N3O
- Molecular Weight:
- 285.3
- MDL Number:
- MFCD16876401
- MOL File:
- 205989-12-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
NFPA 704 |
|
Luotonine A price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 14253 | Luotonin A ≥98% | 205989-12-4 | 1mg | $26 | 2024-03-01 | Buy |
Cayman Chemical | 14253 | Luotonin A ≥98% | 205989-12-4 | 5mg | $96 | 2024-03-01 | Buy |
Cayman Chemical | 14253 | Luotonin A ≥98% | 205989-12-4 | 10mg | $153 | 2024-03-01 | Buy |
Cayman Chemical | 14253 | Luotonin A ≥98% | 205989-12-4 | 25mg | $188 | 2021-12-16 | Buy |
TRC | L474980 | LuotonineA | 205989-12-4 | 25mg | $175 | 2021-12-16 | Buy |
Luotonine A Chemical Properties,Uses,Production
Description
Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine. It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml). Luotonin A is structurally similar to the alkaloid camptothecin and, like camptothecin, it binds to and stabilizes the topoisomerase I-
Uses
Luotonine A is a pyrroloquinoline alkaloid, a topoisomerase I inhibitor and a potent CYP1A inhibitor.
Definition
ChEBI: Luotonin A is a member of quinazolines.
in vitro
luotonin a was isolated as a pyrroloquinazolinoquinoline alkaloid from the chinese medicinal plant peganum nigellastrum. luotonin a could stabilize the human dna topoisomerase i-dna covalent binary complex and mediate topoisomerase i-dependent cytotoxicity in intact cells. similar to camptothecin, luotonin a was able to effect concentration-dependent stabilization of the enzyme-dna binary complex. however, neither camptothecin nor luotonin a had any measurable effect on dna in the absence of topoisomerase i. in addition, luotonin a was evaluated in a strain of saccharomyces cerevisiae lacking yeast topoisomerase i, but having a plasmid having the human topoisomerase i gene under the control of a galactose promoter. results showed that luotonin a at 1 μm concentration could produce 36% inhibition of growth in the presence of galactose. moreover, in replicate experiments, lutonin a exhibited ic50 values from 5.7 to 12.6 μm in the presence of galactose, while the comparable values for camptothecin were from 0.74 to 0.86 μm [1].
IC 50
1.8 μg/ml for p-388 cell line
References
[1] cagir, a. ,jones, s.h.,gao, r., et al. luotonin a. a naturally occurring human dna topoisomerase i poison. journal of the american chemical society 125(45), 13628-13629 (2003).
Luotonine A Preparation Products And Raw materials
Raw materials
Preparation Products
Luotonine A Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
BioPharmaMatrix,Inc. | 0510-86010668 | sales@biopharmamatrix.com | China | 3821 | 55 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56057 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29803 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
Yantai Lianhua Technology Co., Ltd | 15552437730 | 1701654643@qq.com | China | 10866 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |