Luotonine A
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- $26 - $610
- Product name: Luotonine A
- CAS: 205989-12-4
- MF: C18H11N3O
- MW: 285.3
- EINECS:
- MDL Number:MFCD16876401
- Synonyms:Luotonine A;LUMDXNLBIYLTER-UHFFFAOYSA-N;Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one
11 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number6824CR
- Product descriptionLuotoninA
- Packaging5mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4433
- Product descriptionLuotoninA
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4433
- Product descriptionLuotoninA
- Packaging10mg
- Price$131
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4433
- Product descriptionLuotoninA
- Packaging25mg
- Price$261
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14253
- Product descriptionLuotonin A ≥98%
- Packaging1mg
- Price$26
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14253
- Product descriptionLuotonin A ≥98%
- Packaging5mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14253
- Product descriptionLuotonin A ≥98%
- Packaging10mg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14253
- Product descriptionLuotonin A ≥98%
- Packaging25mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number59533
- Product descriptionLuotonineA
- Packaging10mg
- Price$610
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberL474980
- Product descriptionLuotonineA
- Packaging1mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberL474980
- Product descriptionLuotonineA
- Packaging25mg
- Price$175
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 6824CR | LuotoninA | 5mg | $185 | 2021-12-16 | Buy |
| ApexBio Technology | C4433 | LuotoninA | 5mg | $88 | 2021-12-16 | Buy |
| ApexBio Technology | C4433 | LuotoninA | 10mg | $131 | 2021-12-16 | Buy |
| ApexBio Technology | C4433 | LuotoninA | 25mg | $261 | 2021-12-16 | Buy |
| Cayman Chemical | 14253 | Luotonin A ≥98% | 1mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 14253 | Luotonin A ≥98% | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 14253 | Luotonin A ≥98% | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 14253 | Luotonin A ≥98% | 25mg | $188 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59533 | LuotonineA | 10mg | $610 | 2021-12-16 | Buy |
| TRC | L474980 | LuotonineA | 1mg | $45 | 2021-12-16 | Buy |
| TRC | L474980 | LuotonineA | 25mg | $175 | 2021-12-16 | Buy |
Properties
Melting point :283-285 °C
Boiling point :530.9±60.0 °C(Predicted)
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤3mg/ml in DMSO;3mg/ml in dimethyl formamide
form :crystalline solid
pka :1.61±0.20(Predicted)
Boiling point :530.9±60.0 °C(Predicted)
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤3mg/ml in DMSO;3mg/ml in dimethyl formamide
form :crystalline solid
pka :1.61±0.20(Predicted)
Safety Information
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| Signal word: | Danger | ||||||||||||||||
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Description
Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine. It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml). Luotonin A is structurally similar to the alkaloid camptothecin and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM). Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure. Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.Suppliers and manufacturers
J & K SCIENTIFIC LTD.
BioPharmaMatrix,Inc.
Shenzhen Polymeri Biochemical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc
Energy Chemical
Shanghai Maclean Biochemical Technology Co., LTD
Shanghai Yifei Biotechnology Co. , Ltd.
Yantai Lianhua Technology Co., Ltd
ApexBio Technology