IMETIT DIHYDROBROMIDE
- CAS No.
- 32385-58-3
- Chemical Name:
- IMETIT DIHYDROBROMIDE
- Synonyms
- Imetit hydrobromide;Imetit dihydrobromid;IMETIT DIHYDROBROMIDE;VUF 8325 dihydrobromide;SKF 91105 dihydrobromide;S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr;IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE;5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE;S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE;S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
- CBNumber:
- CB7305203
- Molecular Formula:
- C6H12Br2N4S
- Molecular Weight:
- 332.06
- MDL Number:
- MFCD00153816
- MOL File:
- 32385-58-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
IMETIT DIHYDROBROMIDE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I135 | Imetit dihydrobromide ≥98% (HPLC) | 32385-58-3 | 10mg | $162 | 2024-03-01 | Buy |
| Sigma-Aldrich | I135 | Imetit dihydrobromide ≥98% (HPLC) | 32385-58-3 | 25mg | $293 | 2024-03-01 | Buy |
| Alfa Aesar | J62346 | Imetit dihydrobromide, 98% | 32385-58-3 | 50mg | $375.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62346 | Imetit dihydrobromide, 98% | 32385-58-3 | 25mg | $173 | 2021-12-16 | Buy |
| Cayman Chemical | 29517 | Imetit (hydrobromide) | 32385-58-3 | 5mg | $73 | 2024-03-01 | Buy |
IMETIT DIHYDROBROMIDE Chemical Properties,Uses,Production
Description
Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM). It increases scratching in mice (ED50 = 0.9 μmol), an effect that is reduced by the H3 receptor antagonist thioperamide .
Uses
Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.
Definition
ChEBI: A hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces sh pe change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Biological Activity
An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .
Biochem/physiol Actions
Potent and selective H3 histamine receptor agonist.
storage
Store at RT
IMETIT DIHYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
IMETIT DIHYDROBROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |