ML193
- CAS No.
- 713121-80-3
- Chemical Name:
- ML193
- Synonyms
- ML193;CID 1261822;ML-193, 10 mM in DMSO;ML193 trifluoroacetate >=98% (HPLC);N-(4-(N-(3,4-Dimethylisoxazol-5-yl)sulfamoyl)phenyl)-6,8-dimethyl-2-(pyridin-2-yl)quinoline-4-carboxamide;N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide;4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-;Inhibitor,deficits,motor,sensorimotor,CID-1261822,G protein-coupled receptor 55,disease,ML-193,Parkinson,ML193,CID1261822,ML 193,inhibit,GPR55
- CBNumber:
- CB74199381
- Molecular Formula:
- C28H25N5O4S
- Molecular Weight:
- 527.59
- MDL Number:
- MFCD05999971
- MOL File:
- 713121-80-3.mol
ML193 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15184 | ML-193 ≥98% | 713121-80-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15184 | ML-193 ≥98% | 713121-80-3 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 15184 | ML-193 ≥98% | 713121-80-3 | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 15184 | ML-193 ≥98% | 713121-80-3 | 25mg | $381 | 2024-03-01 | Buy |
| Tocris | 4860 | ML193 ≥98%(HPLC) | 713121-80-3 | 10 | $270 | 2021-12-16 | Buy |
ML193 Chemical Properties,Uses,Production
Uses
ML-193 is a potent antagonist of the GPR55 receptor which has been implicated in inflammatory pain and neuropathic pain as well as metabolic disorders and cancer.
Definition
ChEBI: N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide is an aromatic amide.
Biological Activity
ml-193 is a gpr55 antagonist.gpr55 is a class a g protein-coupled receptor (gpcr) that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and cancer. initially deorphanized as a cannabinoid receptor, gpr55 has been shown to be activated by non-cannabinoid ligands such as l-α-lysophosphatidylinositol (lpi).
in vitro
previous study found that for antagonist activity in the β-arrestin trafficking assay, ml193 and its two close analogs (ml191 and ml192) could inhibit trafficking induced by 10 μm lpi with ic50 values of 0.22 ± 0.03, 1.08 ± 0.03 and 0.70 ± 0.05μm, respectively.in addition, it was also found that ml193, ml191 and ml192 was able to inhibit trafficking induced by 1 μm ml186 with ic50 values of 0.12 ±0.02, 1.03 ± 0.03 and 0.29 ± 0.09 μm, respectively [1].
in vivo
animal study showd that ml-193 was able to block the increases in intracellular calcium levels that was induced by lysophosphatidylinositol (lpi) in dissociated rat periaqueductal gray neurons and could also modulate pain perception in lpi-treated rats, suggesting that interfering with gpr55 signaling in the pag might promote analgesia [2].
IC 50
221 nm
storage
Store at -20°C
References
[1] kotsikorou, e. ,sharir, h.,shore, d.m., et al. identification of the gpr55 antagonist binding site using a novel set of high-potency gpr55 selective ligands. biochemistry 52(52), 9456-9469 (2013).
[2] deliu, e. ,sperow, m.,console-bram, l., et al. the lysophosphatidylinositol receptor gpr55 modulates pain perception in the periaqueductal gray. mol.pharmacol. 88(2), 265-272 (2015).
ML193 Preparation Products And Raw materials
Raw materials
Preparation Products
ML193 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1521 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 787 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9329 | 58 |
