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PF-06446846

PF-06446846 Structure
PF-06446846 structure
CAS No.
1632250-49-7
Chemical Name:
PF-06446846
Synonyms
PF-6446846;PF-06446846;Benzamide, N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide;Threonine proteases,PF06446846,Inhibitor,80S ribosome,Selective,PF 06446846,Ser/Thr Protease,Serine proteases,Rat bone marrow,Huh7,inhibit,Serine endopeptidases,PF-06446846
CBNumber:
CB74668360
Molecular Formula:
C22H20ClN7O
Molecular Weight:
433.89
MDL Number:
MFCD32182630
MOL File:
1632250-49-7.mol
Last updated:2023-09-20 16:43:00
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PF-06446846 Properties

Boiling point 655.5±65.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 87 mg/mL (200.51 mM);Ethanol: 87 mg/mL (200.51 mM)
pka 8.69±0.10(Predicted)
Water Solubility Water: Insoluble

PF-06446846 Chemical Properties,Uses,Production

Definition

ChEBI: PF-06446846 is a triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. It has a role as an antilipemic drug and an EC 3.4.21.61 (kexin) inhibitor. It is a monochloropyridine, a member of piperidines, a tertiary carboxamide, a member of benzamides and a triazolopyridine.

PF-06446846 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-06446846 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32835 60
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9977 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 7879 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29786 68
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19105 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62163 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
DC Chemicals 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58

PF-06446846 Spectrum

PF-06446846(1632250-49-7)1HNMR
PF-06446846 PF-6446846 Threonine proteases,PF06446846,Inhibitor,80S ribosome,Selective,PF 06446846,Ser/Thr Protease,Serine proteases,Rat bone marrow,Huh7,inhibit,Serine endopeptidases,PF-06446846 (R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide Benzamide, N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)- 1632250-49-7