ChemicalBook >> CAS DataBase List >>7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one structure

CAS No.: 160129-45-3

Chemical Name:: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Synonyms: 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-chloro-2,3,4,5-tetrahydro-;7-Chlorobenzo[b]azepan-5-one;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

CBNumber:: CB7477186

Molecular Formula:: C10H10ClNO

Molecular Weight:: 195.65

MDL Number:: MFCD06738694

MOL File:: 160129-45-3.mol

MSDS File:: SDS

Last updated:2024-08-12 17:17:06

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Properties

Melting point	103.0 to 107.0 °C
Boiling point	356.5±41.0 °C(Predicted)
Density	1.234±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	2.36±0.20(Predicted)
color	Off-White to Pale Yellow
InChI	InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey	AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES	N1C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	T
Risk Statements	25
Safety Statements	45
HS Code	2933998090

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2896	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T)	160129-45-3	1g	$81	2024-03-01	Buy
TCI Chemical	C2896	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T)	160129-45-3	5g	$321	2024-03-01	Buy
TRC	C366265	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	160129-45-3	10g	$415	2021-12-16	Buy
Usbiological	162272	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	160129-45-3	1g	$418	2021-12-16	Buy
Biosynth Carbosynth	FC51283	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	160129-45-3	100g	$500	2021-12-16	Buy

Product number	Packaging	Price	Buy
C2896	1g	$81	Buy
C2896	5g	$321	Buy
C366265	10g	$415	Buy
162272	1g	$418	Buy
FC51283	100g	$500	Buy

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-Dehydro Tolvaptan

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HEBEI BRANT PHARMACEUTICAL CO.,LTD	+86-311-84455288 +86-18832137600	rice@brantpharm.com	China	17	58
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	yusu@enkibiopharma.com	China	48	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9209	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2963	58

Supplier	Advantage
HEBEI BRANT PHARMACEUTICAL CO.,LTD	58
Enki Biopharmaceuticals (Shanghai) Limited	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-25	7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one 160129-45-3	US $0.00 / kg	25kg	99.0%	10000	Enki Biopharmaceuticals (Shanghai) Limited
2024-10-31	7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 160129-45-3	US $0.00-0.00 / kg	100kg	≥99.0%	20 tons	HEBEI BRANT PHARMACEUTICAL CO.,LTD
2024-09-20	Tolvaptan Impurity 9 160129-45-3	US $0.00-0.00 / mg	10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD

7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one
160129-45-3
US $0.00 / kg
99.0%
Enki Biopharmaceuticals (Shanghai) Limited

7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one
160129-45-3
US $0.00-0.00 / kg
≥99.0%
HEBEI BRANT PHARMACEUTICAL CO.,LTD

Tolvaptan Impurity 9
160129-45-3
US $0.00-0.00 / mg
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Spectrum

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one(160129-45-3)¹HNMR

160129-45-3(7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one)Related Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2

Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE

6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

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7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro- 7-Chlorobenzo[b]azepan-5-one 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one Tolvaptan Impurity 29 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE 7-chloro-2,3,4,5-tetrahydro- 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one > 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine Tovaptan impurity 29 Tovaptan impurity 24 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 160129-45-3 Building Blocks/Intermediates Tolvaptan intermediate