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SHU-9119

SHU-9119 structure

CAS No.: 168482-23-3

Chemical Name:: SHU-9119

Synonyms: SHU-9119;SHU9119，TFA;CHEMBL3422426;SHU9119 (trifluoroacetate salt);AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2;AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG;AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2;Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2);AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2;AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2

CBNumber:: CB7675726

Molecular Formula:: C54H71N15O9

Molecular Weight:: 1074.24

MDL Number:: MFCD01631255

MOL File:: 168482-23-3.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:47

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SHU-9119 Properties

Density	1.43±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	H2O : 20 mg/mL (18.62 mM; Need ultrasonic)
form	Powder
pka	13.00±0.70(Predicted)
color	White to off-white
Water Solubility	Soluble to 0.20 mg/ml in water
Sequence	Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7)

SAFETY

Risk and Safety Statements

WGK Germany	3

SHU-9119 price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	24152	SHU9119 (trifluoroacetate salt) ≥95%	168482-23-3	500μg	$77	2024-03-01	Buy
Cayman Chemical	24152	SHU9119 (trifluoroacetate salt) ≥95%	168482-23-3	1mg	$121	2024-03-01	Buy
Tocris	3420	SHU9119	168482-23-3	1	$151	2021-12-16	Buy
Usbiological	256659	SHU 9119	168482-23-3	1mg	$389	2021-12-16	Buy
ChemScene	CS-6496	SHU9119 98.21%	168482-23-3	5mg	$468	2021-12-16	Buy

Product number	Packaging	Price	Buy
24152	500μg	$77	Buy
24152	1mg	$121	Buy
3420	1	$151	Buy
256659	1mg	$389	Buy
CS-6496	5mg	$468	Buy

SHU-9119 Chemical Properties,Uses,Production

Description

SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC₅₀s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC₅₀ = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.

Uses

SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

in vivo

Blockade of CNS-Mcr via chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats compared with control. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment potently increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase^[2]. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (?42%). In addition, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (?60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity^[3].

IC 50

MC3R; MC4R; MC5R

storage

Store at -20°C

References

[1] Grieco P, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 2007 Jun;28(6):1191-6. DOI:10.1016/j.peptides.2007.02.012
[2] Nogueiras R, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117(11):3475-88. DOI:10.1172/JCI31743
[3] Kooijman S, et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55(10):2022-32. DOI:10.1194/jlr.M045989

SHU-9119 Preparation Products And Raw materials

Raw materials

Preparation Products

SHU-9119 Suppliers

Global( 102)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Adachibio Inc.	+81-8027837258 +8108027837258	sales@adachi-bio.com	Japan	992	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19841	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32239	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30230	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58

Supplier	Advantage
Adachibio Inc.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58

168482-23-3(SHU-9119)Related Search:

ALPHA-MSH ALPHA-MSH SHU 9119, [125I]- SHU-9119 Melanotan II

SHU-9119 [N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2 AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2 (AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10) (AC-NLE4,ASP5,D-ALA(2-NAPHTHYL)7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2 AC-NLE-CYCLO(-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2) TRIFLUOROACETATE SALT AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2 AC-NLE-CYCLO(BETA-ASP-HIS-D-2-NAL-ARG-TRP-EPSILON-LYS)-NH2 AC-NLE-CYCLO(-BETA-ASP-HIS-D-ALA(2-NAPHTHYL)-ARG-TRP-EPSILON-LYS-NH2) [ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE [ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MSH (4-10) AMIDE (ACETYL-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE TRIFLUOROACETATE SALT (Ac-Nle4,Asp5,D-Ala(2-naphthyl)7,Lys10)-cyclo-a-MSH (4-10) amide Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10 Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) aMide SHU9119 Ac-Nle-Asp-His-D-Nal(2)-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10) Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-a-MSH (4-10) aMide Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2) Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-Alpha-MSH (4-10) amide SHU9119 (trifluoroacetate salt) L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide trifluoroacetate salt CHEMBL3422426 Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide, SHU9119 Acetyl-(Nle?,Asp?,D-2-Nal?,Lys1?)-cyclo-α-MSH (4-10) amide trifluoroacetate salt Acetyl-(Nle?,Asp?,D-2-Nal?,Lys??)-cyclo-α-MSH (4-10) amide trifluoroacetate salt SHU9119，TFA (3R,6R,9S,12R,15R,23R)-12-((1H-Imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((R)-2-acetamidohexanamido)-6-(3-guanidinopropyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist N-Acetyl-L-norleucyl-L-a-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide-(2,7) -lactam 168482-23-3 C54H71N15O9