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Thymosin α1

CAS No.
62304-98-7
Chemical Name:
Thymosin α1
Synonyms
THYMOSIN A1;THYMOSIN ALPHA 1;ZADAXIN;Thymosin α1 Acetate;Thymosin α1 Acetate;Thymosin α1;Thymosin Alpha;THYMOSIN APHA 1;Thymosina1Acetate;ThyMosins alpha 1
CBNumber:
CB7678989
Molecular Formula:
C129H215N33O55
Molecular Weight:
3108.32
MDL Number:
MFCD00076889
MOL File:
62304-98-7.mol
MSDS File:
SDS
Last updated:2024-12-10 11:57:34

Thymosin α1 Properties

Boiling point 2899.7±65.0 °C(Predicted)
Density 1.360±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
form A crystalline solid
color Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Stability Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
InChIKey NZVYCXVTEHPMHE-WTRFZTBJNA-N
FDA UNII W0B22ISQ1C

SAFETY

Risk and Safety Statements

WGK Germany  3

Thymosin α1 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T3410 Thymosin α1 bovine ≥90% (HPLC) 62304-98-7 0.5mg $318 2024-03-01 Buy
Sigma-Aldrich T3410 Thymosin α1 bovine ≥90% (HPLC) 62304-98-7 0.1mg $245 2023-06-20 Buy
Cayman Chemical 28748 Thymosin α1 (human, mouse, rat, bovine) 62304-98-7 500μg $81 2024-03-01 Buy
Cayman Chemical 28748 Thymosin α1 (human, mouse, rat, bovine) 62304-98-7 10mg $869 2024-03-01 Buy
Cayman Chemical 28748 Thymosin α1 (human, mouse, rat, bovine) 62304-98-7 1mg $137 2024-03-01 Buy
Product number Packaging Price Buy
T3410 0.5mg $318 Buy
T3410 0.1mg $245 Buy
28748 500μg $81 Buy
28748 10mg $869 Buy
28748 1mg $137 Buy

Thymosin α1 Chemical Properties,Uses,Production

Description

Thymosin-α1 (T-α1), a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement, this drug is used for the treatment of HBV and hepatitis C virus (HCV) infections, and being developed for the treatment of non-small cell lung cancer (NSCLC), hepatocellular carcinoma, AIDS and malignant melanoma. T-α1 is able to potentiate the action of cytokines and also reduce the hematological toxicity of cytotoxic drug therapy, such as cyclophosphamide, 5-fluorouracil, dacarbazine.

Description

Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.

Uses

Zadax-in (SciClone).
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.
Immune enhancing peptide
Helps prevent infections such as the common cold or the flu and diseases
Reduces inflammation in the body
Aids in the removal of acute or chronic infections
Has antibacterial, antiviral, and antifungal properties
Supports the eradication of unhealthy cells
Protects your cells against oxidative stress and damage
Inhibits viral replication
Improve symptoms associated with chronic fatigue
Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections.
https://www.ncbi.nlm.nih.gov

Definition

ChEBI: Thymalfasin is a polypeptide.

Biological Functions

Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
https://www.prospecbio.com

Synthesis Reference(s)

Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can only be chemosynthesized because of two obstacles to its biosynthesis: the difficulties in expressing small peptides and obtaining Nα-acetylation. In this study, we describe a novel production process for Nα-acetylated Tα1 in Escherichia coli.
Synthesis of Thymosin α1, a Polypeptide of the Thymus
Production of Nα-acetylated thymosin α1 in Escherichia coli
Synthesis of thymosin .alpha.1

Clinical claims and research

Thymosin α1 (Tα1) is a 28 amino acid peptide produced by thymic epithelial cellslocated in the outer cortex and medulla of the thymus (Hirokawa et al., 1982).Invitro studies involving the use of bone marrow and progenitor cell cocultures haverevealed Tα1's capacity to stimulate thymocyte maturation (Knutsen et al.,1999).Inaddition,the administration of Tα1 in mice has resulted in notable increases inmurine thymic size and thymocyte numbers,further demonstrating Tal's abilityto enhance thymocyte growth (Beuth et al., 2000).Tα1 is likely to exert its stimula-tory effect on developing thymocytes partly by acting as an anti-apoptotic agent(Baumann et al.,1996). Interestingly,the addition of Tα1 to thymocyte andthymic epithelial cell cocultures was found to increase the production of IL-7 byepithelial cells, suggesting that the enhancing effect of Tal on thymopoiesis may bethrough the induction of IL-7 (Knutsen et al.,1999).
Basic Biology and Clinical Impact of Immunosenescence

Thymosin α1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 351)Suppliers
Supplier Tel Email Country ProdList Advantage
Cellmano Biotech Limited
0551-65326643 18156095617 info@cellmano.com China 999 58
Zhuzhou New Peptides Tech Co.,Ltd.
+86-18073326374 +86-18073326374 sales@goodpeptides.com China 56 58
BOC Sciences
16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Apeloa production Co.,Limited
+8619933239880 admin@apcl.com.cn China 852 58
Shanghai Likang New Materials Co., Limited
+86-16631818819 +86-17736933208 3684455296@qq.com China 9300 58
Hebei Xunou new energy Technology Co., LTD
+86-17531957005; +undefined17531957005 xunou8@hbxunou.com China 36 58
Rixing Chemical CO.,LTD.
+86-852-57055271 +8613237129059 sales@rixingbiz.com China 232 58
Huaian Banting Trading Co., Ltd.
+undefined13102576090 sales5@bantingpeptide.com China 38 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599 info@molchanges.com China 5223 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
THYMOSIN ALPHA 1 pictures 2024-12-23 THYMOSIN ALPHA 1
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US $50.00-30.00 / box 1box 99.9% 1000box hebei hongtan Biotechnology Co., Ltd
Thymosin α1 pictures 2024-12-23 Thymosin α1
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US $30.00 / box 1box 98% 2000box hebei hongtan Biotechnology Co., Ltd
Thymosin Alpha-1 pictures 2024-12-23 Thymosin Alpha-1
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US $15.00 / mg 100mg 99% 10000000 Hebei Jiafan Trading Company Limited
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  • 99.9%
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  • US $30.00 / box
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  • Thymosin Alpha-1
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  • US $15.00 / mg
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Thymosina1Acetate Thymosin α1, Thymalfasin ACETYL-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN-OH THYMOSIN A1 BOVINE THYMOSIN ALPHA1 BOVINE THYMOSIN APHA 1 Thymosin α 1 Acetate(Thymalfasin) thymosin α1 bovine AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN: AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN Thymosinα1 bovine,Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn ThyMosins alpha 1 Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH acetate salt Thymalfasin/Thymosin α1 Acetate Thymosin α1 (cattle) Thymalfasin (Thymosin α1) Thymosin α1 Thymosin α1 (human, mouse, rat, bovine) Thymosin α1(Thymalfasin) Injectable Lyophillzed Powder Peptides Peptide Thymosin Acetate/Thymosin Alpha-1/Thymosin 10mg/Vial Thymosin α1 USP/EP/BP Thymosin αAcetate salt Thymalfasin Acetate salt Thymalfasin/Thymosin α1 Acetate alpha 1 Thymosin α1 THYMOSIN A1 THYMOSIN ALPHA 1 ZADAXIN Thymosin α1 Acetate Thymosin α1 Acetate Thymalfasin (Thymosin a1) Thymosin Alpha Thymosin alpha-1/Thymosin α1 Thymosin α1 bovine 62304-98-7 162304-98-7 C129H215N33O55 Peptides Immunomodulators BioChemical Biochemicals and Reagents Amino Acids and Peptides Amino Acid Derivatives Peptide Various Peptides 62304-98-7