1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- CAS No.
- 321-64-2
- Chemical Name:
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- Synonyms
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE;Tetrahydroaminoacridine;C01453;acrine;cs12602;CS 12602;AKOS 221-09;Tacrine 321-64-2;BUTTPARK 20\04-06;Tetrahydroaminocrin
- CBNumber:
- CB7699634
- Molecular Formula:
- C13H14N2
- Molecular Weight:
- 198.26
- MDL Number:
- MFCD00046923
- MOL File:
- 321-64-2.mol
- MSDS File:
- SDS
| Melting point | 183.5℃ |
|---|---|
| Boiling point | 325.59°C (rough estimate) |
| Density | 0.9827 (rough estimate) |
| refractive index | 1.4400 (estimate) |
| storage temp. | 4°C, away from moisture and light |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9?+-.0.20(Predicted) |
| color | White to Pale Yellow |
| CAS DataBase Reference | 321-64-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4VX7YNB537 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH011632 | 1,2,3,4-tetrahydro-9-acridinamine AldrichCPR | 321-64-2 | 500mg | $172 | 2023-06-20 | Buy |
| American Custom Chemicals Corporation | API0004308 | TACRINE 95.00% | 321-64-2 | 0.5G | $682 | 2021-12-16 | Buy |
| Acrotein | H-0509 | 1,2,3,4-Tetrahydro-9-aminoacridine 97% | 321-64-2 | 1g | $174.17 | 2021-12-16 | Buy |
| ACHEMBLOCK | P38835 | 1,2,3,4-Tetrahydro-9-aminoacridine 95% | 321-64-2 | 1G | $235 | 2021-12-16 | Buy |
| Ambeed | A295785 | 1,2,3,4-Tetrahydroacridin-9-amine 98% | 321-64-2 | 25g | $337 | 2021-12-16 | Buy |
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Chemical Properties,Uses,Production
Description
In the 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In the 1960s, tacrine was used to reverse the effects of phencyclidine-like drugs. It was also marketed for many years as a respiratory stimulant. In 1993, the US Food and Drug Administration approved tacrine for the treatment of symptoms of mild to moderate Alzheimer’s disease.
Uses
The current use of tacrine is limited due to its poor oral bioavailability, the necessity for four daily doses, and serious side effects (including nausea, vomiting, dry mouth, indigestion, diarrhea, loss of appetite, urinary incontinence, collapse, convulsions, and hepatotoxicity). Currently, newer cholinesterase inhibitors (such as donepezil, rivastigmine, and galantamine) are preferred over tacrine.
Definition
ChEBI: Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+).
Synthesis Reference(s)
Tetrahedron Letters, 4, p. 1277, 1963 DOI: 10.1039/jr9630005127
Toxicity evaluation
Tacrine has numerous mechanisms of action. The putative
principal mechanism of action of tacrine for Alzheimer’s
disease is reversible inhibition of acetylcholinesterase (AChE),
which thereby slows the breakdown of the chemical messenger
acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase
activity. In addition, tacrine blocks sodium
and potassium channels. Tacrine also acts as a histamine
N-methyltransferase inhibitor.
At a therapeutic dose, tacrine causes liver toxicity. Cytotoxicity
studies using the human liver cell line HepG2 showed that
a therapeutic blood concentration of tacrine induces reactive
oxygen species production and glutathione depletion, suggesting
that oxidative stress might be involved in tacrine
hepatotoxicity.
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18151 | 58 |
View Lastest Price from 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
321-64-2
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-17 | tacrine
321-64-2
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
321-64-2
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- tacrine
321-64-2
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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