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CHROMANOL 293B

CHROMANOL 293B Structure
CHROMANOL 293B structure
CAS No.
163163-23-3
Chemical Name:
CHROMANOL 293B
Synonyms
Chromagnol;CHROMANOL 293B;Chromanol 293B >=98% (HPLC), powder;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane;N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide;TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE;Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
CBNumber:
CB7710010
Molecular Formula:
C15H20N2O4S
Molecular Weight:
324.4
MDL Number:
MFCD06799499
MOL File:
163163-23-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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CHROMANOL 293B Properties

Boiling point 474.1±55.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: 18 mg/mL
pka 12.96±0.60(Predicted)
form solid
color white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36/37-7/9
WGK Germany  3
NFPA 704
0
3 0

CHROMANOL 293B price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C2615 Chromanol 293B ≥98% (HPLC), powder 163163-23-3 10mg $124.2 2024-03-01 Buy
Sigma-Aldrich C2615 Chromanol 293B ≥98% (HPLC), powder 163163-23-3 50mg $904 2024-03-01 Buy
Cayman Chemical 19993 Chromanol 293B ≥98% 163163-23-3 1mg $32 2024-03-01 Buy
Cayman Chemical 19993 Chromanol 293B ≥98% 163163-23-3 5mg $116 2024-03-01 Buy
Cayman Chemical 19993 Chromanol 293B ≥98% 163163-23-3 10mg $169 2024-03-01 Buy
Product number Packaging Price Buy
C2615 10mg $124.2 Buy
C2615 50mg $904 Buy
19993 1mg $32 Buy
19993 5mg $116 Buy
19993 10mg $169 Buy

CHROMANOL 293B Chemical Properties,Uses,Production

Description

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.

Uses

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

General Description

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Biological Activity

Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).

Biochem/physiol Actions

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

storage

Room temperature

CHROMANOL 293B Preparation Products And Raw materials

Raw materials

Preparation Products

CHROMANOL 293B Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14055 65
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44808 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
Sigma-Aldrich 80
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
MedBioPharmaceutical Technology Inc 58

163163-23-3(CHROMANOL 293B)Related Search:

2,2-DIMETHYLCHROMANE Ethanesulfonamide (-)-[3R,4S]-CHROMANOL 293B,Chromanol 293B [3R,4S]-(-)- 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE CHROMANOL 293B
4-TERT-BUTOXYBENZONITRILE (S)-3-(1-Aminoethyl)benzonitrile 2-(3-CYANO-PHENYL)ETHANOL

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TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE CHROMANOL 293B 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide Chromagnol Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel- Chromanol 293B >=98% (HPLC), powder 163163-23-3 Potassium channel