BQ-788
- CAS No.
- 156161-89-6
- Chemical Name:
- BQ-788
- Synonyms
- CS-1494;BQ-788 SODIUM;BQ789 Sodium Salt;1-ELAIDYLPHOSPHOCHOLINE, >97%;BQ788 SODIUM SALT; BQ 788 SODIUM SALT;BQ 788 sodium salt, ETB receptor antagonist;BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT;N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-;N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa;2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
- CBNumber:
- CB7710904
- Molecular Formula:
- C34H52N5NaO7
- Molecular Weight:
- 665.81
- MDL Number:
- MFCD00797882
- MOL File:
- 156161-89-6.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| solubility | acetonitrile: 0.3 mg/mL |
| form | solid |
| color | white |
| Water Solubility |
acetonitrile: 0.3mg/mL DMSO: 1.2mg/mL ethanol: 1.2mg/mL H2O: slightly soluble |
| FDA UNII | 44OLL8XEJ4 |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
BQ-788 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B157 | BQ-788 ≥95%,solid | 156161-89-6 | 200μg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 17403 | BQ-788 (sodium salt) ≥95% | 156161-89-6 | 500μg | $175 | 2024-03-01 | Buy |
| Cayman Chemical | 17403 | BQ-788 (sodium salt) ≥95% | 156161-89-6 | 1mg | $242 | 2024-03-01 | Buy |
| TRC | B676670 | BQ788 | 156161-89-6 | 5mg | $595 | 2021-12-16 | Buy |
| ChemScene | CS-2685 | BQ-788(sodiumsalt) 98.03% | 156161-89-6 | 10mg | $600 | 2021-12-16 | Buy |
BQ-788 Chemical Properties,Uses,Production
Uses
BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs), uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs)
Biological Activity
Potent, selective ET B receptor antagonist (IC 50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
Biochem/physiol Actions
Selective ETB endothelin receptor antagonist.
in vivo
BQ-788 (3 mg/kg/h, i.v.) completely inhibits a pharmacological dose of ET-1- or sarafotoxin6c (0.5 nmol/kg, i.v.)-induced ETB receptor-mediated depressor, but not pressor responses in conscious rats. Furthermore, BQ-788 markedly increases the plasma concentration of ET-1, which is considered an index of potential ETB receptor blockade in vivo. In Dahl salt-sensitive hypertensive (DS) rats, BQ-788 (3 mg/kg/h, i.v.) increases blood pressure by about 20 mm Hg. It is reported that BQ-788 also inhibits ET-1-induced bronchoconstriction, tumor growth and lipopolysaccharide-induced organfailure[1]. BQ 788 (3 mg/kg) results in an eightfold leftward shift in the ET-1 dose-response curve, suggesting a significant involvement of ETB dilator receptors[2]. Mice are treated with 30 nmol BQ-788 by intraplantar, reduce mechanical hyperalgesia (47% and 42%), thermal hyperalgesia (68% and 76%), oedema (50% and 30%); myeloperoxidase activity (64% and 32%), and overt-pain like behaviours. Additionally, intraplantar treatment with clazosentan or BQ-788 decreases spinal (45% and 41%) and peripheral (47% and 47%) superoxide anion production as well as spinal (47% and 47%) and peripheral (33% and 54%) lipid peroxidation, respectively[3].
IC 50
ETB
storage
+4°C
BQ-788 Preparation Products And Raw materials
Raw materials
Preparation Products
BQ-788 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19889 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11598 | 64 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6627 | 58 |
View Lastest Price from BQ-788 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | BQ-788 sodium salt
156161-89-6
|
US $285.00-1270.00 / mg | 10g | TargetMol Chemicals Inc. |
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- BQ-788 sodium salt
156161-89-6
- US $285.00-1270.00 / mg
- TargetMol Chemicals Inc.