Cytidine
- CAS No.
- 65-46-3
- Chemical Name:
- Cytidine
- Synonyms
- 4-aMino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one;Cyd;Citydine;Cytosine β-D-riboside;Citidine;Cytidin;Cytidine;Cytinide;Cytidylic;Cytidine >
- CBNumber:
- CB7854079
- Molecular Formula:
- C9H13N3O5
- Molecular Weight:
- 243.22
- MDL Number:
- MFCD00006545
- MOL File:
- 65-46-3.mol
- MSDS File:
- SDS
| Melting point | 210-220 °C (dec.) (lit.) |
|---|---|
| Boiling point | 386.09°C (rough estimate) |
| alpha | 31.5 º (c=0.6, H2O 25 ºC) |
| Density | 1.3686 (rough estimate) |
| refractive index | 34 ° (C=0.7, H2O) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 4.22, 12.5(at 25℃) |
| color | White to almost white |
| PH | 4.13 |
| biological source | synthetic |
| optical activity | [α]20/D +33°, c = 2 in H2O |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| λmax | 280 (pH 1)；229.5，271 (pH 7) |
| Merck | 14,2786 |
| BRN | 89173 |
| Stability | Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| LogP | -1.808 (est) |
| CAS DataBase Reference | 65-46-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 5CSZ8459RP |
| NIST Chemistry Reference | Cytidine(65-46-3) |
| EPA Substance Registry System | Cytidine (65-46-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.75 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Risk Statements | 68 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UW7370000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 2700mg/kg | |||||||||
| NFPA 704 |
|
Cytidine price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C122106 | Cytidine 99% | 65-46-3 | 1g | $27.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | C122106 | Cytidine 99% | 65-46-3 | 10g | $74 | 2024-03-01 | Buy |
| TCI Chemical | C0522 | Cytidine >98.0%(HPLC)(T) | 65-46-3 | 1g | $27 | 2024-03-01 | Buy |
| TCI Chemical | C0522 | Cytidine >98.0%(HPLC)(T) | 65-46-3 | 5g | $49 | 2024-03-01 | Buy |
| Alfa Aesar | A10261 | Cytidine, 99% | 65-46-3 | 10g | $59.65 | 2024-03-01 | Buy |
Cytidine Chemical Properties,Uses,Production
Structure
The crystal specimens were kindly supplied by Dr. D. O. Jordan, University of Nottingham, and were found to be orthorhombic with {110} dominating. An optical investigation shows that the sign is positive, with α∥c, β∥b and γ∥a. Cell dimensions are: a = 13·93 A., b = 14·75 A., c = 5·10 A.; density, 1·53; four molecules per unit cell; space-group, P 212121.
Description
Cytidine is a pyrimidine nucleoside that is composed of the pyrimidine base cytosine attached to the sugar ribose. As a constituent of RNA, cytidine pairs with guanine, and it is a precursor of uridine. Cytidine can incur several modifications in mRNA, including methylation and acetylation, that function to regulate translation. Cytidine can also be formylated to 5-formylcytidine in mitochondrial methionine transfer RNA (tRNAMet).
Chemical Properties
Cytidine is a component of RNA. It is a white water-soluble solid. which is only slightly soluble in ethanol.There are a variety of cytidine analogs with potentially useful pharmacology.
Uses
Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA. It was isolated from yeast nucleic acid. It can increases cell membrane phospholipids. Cytidine is used to synthesize enzyme inhibitors, antiviral agents, and anticancer agents. And also used as constituent of nucleic acids.
Application
Cytidine has been used as a non-essential aminoacid component of minimal essential medium (MEM) to analyse interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts. It has also been used as a supplement in the culture medium of HeLa cells, to study the effects of cytidine addition on rods and rings (RR) induced by glutamine deprivation.
Cytidine has been used as a component to prepare ribonucleoside stock solution to assess its effects on the anaerobic growth of several Bacillus mojavensis strains.
Definition
ChEBI: cytidine is a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N(1)-glycosidic bond. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a cytosine.The derivednucleotides, cytidine mono-, di-, andtriphosphate (CMP, CDP, and CTP respectively)participate in various biochemicalreactions, notably inphospholipid synthesis.
General Description
White crystalline powder.
Air & Water Reactions
Cytidine is hygroscopic. Water soluble.
Reactivity Profile
Cytidine is incompatible with strong oxidizing agents. . Will react as a weak base.
Fire Hazard
Flash point data for Cytidine are not available; however, Cytidine is probably combustible.
Purification Methods
Cytidine crystallises from 90% aqueous EtOH. It has also been converted to sulfate by dissolving (~200mg) in a solution of EtOH (10mL) containing H2SO4 (50mg), whereby the salt crystallises out. It is collected, washed with EtOH and dried for 5hours at 120o/0.1mm. The sulfate has m 225o. The free base is obtained by shaking the salt solution with a weak ion-exchange resin, filtering, evaporating and recrystallising the residue from EtOH as before. [Fox & Goodman J Am Chem Soc 73 3256 1956, Fox & Shugar Biochim Biophys Acta 9 369 1952; see Prytsas & Sorm in Synthetic Procedures in Nucleic Acid Chemistry (Zorbach & Tipson Eds) Vol 1 404 1973.] [Beilstein 25 III/IV 3667.]
Cytidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| weifang runzhong fine chemical co., ltd | 536-7868377 +8618653686003 | sq@runzhongchem.com | China | 187 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| Hangzhou Measure Life Technology Co., LTD | +8613343730176 | 2924244016@qq.com | China | 83 | 58 |
| Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +8618001850931 | sales@meiyapharm.com | China | 58 | 58 |
| Wuhan Fortuna Chemical Co.,Ltd | +8618007136271 | hk@fortunachem.com | China | 5992 | 58 |
| Xinxiang Aurora Biotechnology Co.,Ltd. | +86-0086-0373-3088722 +8618637352520 | info@aurora-biotech.com | China | 97 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5975 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
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View Lastest Price from Cytidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Cytidine
65-46-3
|
US $0.00 / Kg/Drum | 1KG | 99%min HPLC | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-28 | Cytidine
65-46-3
|
US $0.00-0.00 / kg | 1kg | ≥99% | 20 tons | Hangzhou Meiya Pharmaceutical Co Ltd | |
 |
2025-04-28 | Cytidine
65-46-3
|
US $55.00 / kg | 1kg | 99% | 20 tons | Hebei Zhuanglai Chemical Trading Co Ltd |