ChemicalBook >> CAS DataBase List >>(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID structure

CAS No.: 89396-94-1

Chemical Name:: (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID

Synonyms: TA 6366;Novaloc;SH-6366;Novarok;Tanapril;Tanatril;ACE/TA-6366;IMipadril HCl;Imidaprilhydrochloride;Imidapril HCl (TA-6366)

CBNumber:: CB81009271

Molecular Formula:: C20H27N3O6

Molecular Weight:: 405.44488

MDL Number:: MFCD00923828

MOL File:: 89396-94-1.mol

Last updated:2023-06-08 17:06:35

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(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Properties

Melting point	214-216℃
alpha	D20 -64.1° (c = 0.5 in ethanol)
storage temp.	-20°C
solubility	H2O: ≥5mg/mL
form	powder
color	white to tan
optical activity	[α]/D -50 to -70° in ethanol (c=0.5)
Merck	14,4911
FDA UNII	7NSF9GG1NU

Pharmacokinetic data

Protein binding	85%
Excreted unchanged in urine	9 (as imidaprilat)
Biological half-life	2 / Increased (>24 hours as imidaprilat)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H315-H319-H361

Precautionary statements

P501-P202-P201-P264-P280-P302+P352-P308+P313-P337+P313-P305+P351+P338-P362+P364-P332+P313-P405

WGK Germany

RTECS

NI8927400

HS Code

2933.29.4300

NFPA 704

	0
2		0

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0148	Imidapril hydrochloride ≥98% (HPLC)	89396-94-1	10mg	$77.4	2024-03-01	Buy
Sigma-Aldrich	SML0148	Imidapril hydrochloride ≥98% (HPLC)	89396-94-1	50mg	$505	2024-03-01	Buy
TCI Chemical	I0901	Imidapril Hydrochloride >98.0%(HPLC)(T)	89396-94-1	25mg	$126	2024-03-01	Buy
TCI Chemical	I0901	Imidapril Hydrochloride >98.0%(HPLC)(T)	89396-94-1	100mg	$343	2024-03-01	Buy
Alfa Aesar	H37392	Imidapril (hydrochloride) 98%	89396-94-1	1g	$437.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0148	10mg	$77.4	Buy
SML0148	50mg	$505	Buy
I0901	25mg	$126	Buy
I0901	100mg	$343	Buy
H37392	1g	$437.65	Buy

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Uses

Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.

Uses

antibiotic

Definition

ChEBI: Imidapril hydrochloride is a dipeptide.

General Description

Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.

Biochem/physiol Actions

Imidapril is a potent angiotensin converting enzyme inhibitor and anti-hypertensive.

Clinical Use

Angiotensin-converting enzyme inhibitor:

Hypertension

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion, possibility of enhanced lithium toxicity.
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Imidapril is a prodrug, and is metabolised in the liver to the diacid imidaprilat, its active metabolite. The bioavailability of imidaprilat is about 42% after oral doses of imidapril.
About 40% of an oral dose is excreted in the urine, the rest in the faeces.

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Suppliers

Global( 165)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Xi'an MC Biotech, Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58

View Lastest Price from (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-06-26	Imidapril hydrochloride 89396-94-1	US $150.00 / ASSAYS	10g	>99%	500kg/month	Hebei Mingeng Biotechnology Co., Ltd
	2019-07-10	(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID 89396-94-1	US $33.00 / KG	1KG	99%	1000kg	Career Henan Chemical Co

Imidapril hydrochloride
89396-94-1
US $150.00 / ASSAYS
>99%
Hebei Mingeng Biotechnology Co., Ltd

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
89396-94-1
US $33.00 / KG
99%
Career Henan Chemical Co

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Spectrum

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID(89396-94-1)¹HNMR

89396-94-1((S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID)Related Search:

Imidapril Cefaclor Tariquidar Valsartan Lopinavir

MPI-0479605 Ramipril

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(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID: HYDROCHLORIDE ACE/TA-6366 Novarok SH-6366 Imidaprilhydrochloride 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, (4S)- 4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, [4S-[3[R*(R*)],4R*]]- Novaloc TA 6366 Tanapril Tanatril Imidapril hydrochloride [jan] Imidapril monohydrochloride 3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride IMipadril HCl IMidapril HCL & its interMediates 4-IMidazolidinecarboxylicacid,3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]-1-Methyl-2-oxo-,hydrochloride (1:1), (4S)- 4-Imidazolidinecarboxylicacid,3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-,hydrochloride (1:1) (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid,hydrochloride (-)-(4S)-3-[2(S)-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride ImidaprilHydrochloride> IMidapril Hydrochloride USP/EP/BP (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID USP/EP/BP (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride Imidapril HCl (TA-6366) Imidapril Hydrochloride (cGMP) (-)-(4S)-3-[2(S)-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]am... Imidapril Hydrochloride (secondary standard) 89396-94-1 C20H27N3O6HCl C20H28ClN3O6 C20H27N3O6ClH Inhibitors