ChemicalBook >> CAS DataBase List >>PERTUSSIS TOXIN
PERTUSSIS TOXIN
- CAS No.
- 70323-44-3
- Chemical Name:
- PERTUSSIS TOXIN
- Synonyms
- PTX;iap;HOLOTOXIN;IAG2;ALPI;MAGT1;PSEC0084;pertussigen;UNQ628/PRO1244;pertussistoxins
- CBNumber:
- CB8145592
- Molecular Formula:
- NULL
- Molecular Weight:
- 0
- MDL Number:
- MFCD00131841
- MOL File:
- Mol file
Last updated:2024-07-02 08:55:18
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | T,B,Xi |
| Risk Statements | 23/24/25-36/37/38 |
| Safety Statements | 36/37/39-45-26 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | XW5883750 |
| F | 10 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
PERTUSSIS TOXIN price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7208 | Pertussis toxin from Bordetella pertussis lyophilized powder | 70323-44-3 | 50μg | $592 | 2024-03-01 | Buy |
| Sigma-Aldrich | P2980 | Pertussis toxin from Bordetella pertussis buffered aqueous glycerol solution | 70323-44-3 | 50μg | $628 | 2024-03-01 | Buy |
| Sigma-Aldrich | P2980 | Pertussis toxin from Bordetella pertussis buffered aqueous glycerol solution | 70323-44-3 | 0.2mg | $2100 | 2024-03-01 | Buy |
| Sigma-Aldrich | 516561 | Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. | 70323-44-3 | 50μG | $489 | 2024-03-01 | Buy |
| Sigma-Aldrich | 516560 | Pertussis Toxin, Bordetella pertussis - CAS 70323-44-3 - Calbiochem This Pertussis toxin, CAS 70323-44-3, catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt. | 70323-44-3 | 50μG | $489 | 2024-03-01 | Buy |
PERTUSSIS TOXIN Chemical Properties,Uses,Production
Uses
The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.
General Description
Product is not activated. If activation is required, see Kaslow, et al., for suggested conditions.
Biochem/physiol Actions
Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.
storage
Store at +4°C
Purification Methods
Purify the toxin by stepwise elution from 3 columns comprising Blue Sepharose, Phenyl Sepharose and hydroxylapatite, and the purity is checked by SDS-PAGE. [Svoboda et al. Anal Biochem 159 402 1986, Biochemistry 21 5516 1982, Biochem J 83 295 1978.]
PERTUSSIS TOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
PERTUSSIS TOXIN Suppliers
Global( 67)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 16168 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Beijing OKA biological technology co., LTD | 010-010-010-62971590 18548936886 | jack@oka-vip.com | China | 6897 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
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DISCONTINUED
HOLOTOXIN
PTX
iap
70323-44-3
C87H162N14O16S2
Cell Biology
Cell Signaling and Neuroscience
BioChemical
G Proteins and Cyclic Nucleotides
G Protein Function
Reagents
G-Protein