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PERTUSSIS TOXIN

PERTUSSIS TOXIN Suppliers list
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Products Intro: Product Name:PERTUSSIS TOXIN
CAS:70323-44-3
Purity:99% Package:1kg
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Pertussis Toxin
CAS:70323-44-3
Purity:98.00% Package:1 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
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Products Intro: Product Name:Pertussis Toxin
CAS:70323-44-3
Purity:- Package:50μg
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580
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Products Intro: Product Name:Pertussis Toxin
CAS:70323-44-3
Purity:0.99 Package:100g;1kg;5KG;1KG
Company Name: Absin Bioscience Inc.  Gold
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Products Intro: Product Name:Pertussis Toxin
CAS:70323-44-3
Purity:>99% Package:50ug/
PERTUSSIS TOXIN Basic information
Product Name:PERTUSSIS TOXIN
Synonyms:histamine-sensitizingfactor;Protein-based AB5-type exotoxin with five dissimilar subunits: S-1 (M.W. 28 kDa), S-2 (M.W. 23 kDa), S-3 (M.W. 22 kDa), S-4 (M.W. 11.7 kDa) and S-5 (M.W. 9.3 kDa), in a molar ratio of 1:1:1:2:1;Pertussis toxin from Bordetella pertussis,Histamine-sensitizing factor, IAP, Islet Activating Protein, Pertussigen;ANTI-ALKALINE PHOSPHATASE (ALPI) (CENTER antibody produced in rabbit;ANTI-MAGT1 (N-TERM) antibody produced in rabbit;IAG2;Implantation-associated protein;Magnesium transporter protein 1
CAS:70323-44-3
MF:NULL
MW:0
EINECS:
Product Categories:G-Protein
Mol File:Mol File
PERTUSSIS TOXIN Structure
PERTUSSIS TOXIN Chemical Properties
storage temp. 2-8°C
solubility Water: soluble
form lyophilized powder
color White to off-white
Safety Information
Hazard Codes T,B,Xi
Risk Statements 23/24/25-36/37/38
Safety Statements 36/37/39-45-26
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS XW5883750
10
HazardClass 6.1(a)
PackingGroup I
MSDS Information
ProviderLanguage
SigmaAldrich English
PERTUSSIS TOXIN Usage And Synthesis
UsesThe toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.
General DescriptionProduct is not activated. If activation is required, see Kaslow, et al., for suggested conditions.
Biochem/physiol ActionsPertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.
storageStore at +4°C
Purification MethodsPurify the toxin by stepwise elution from 3 columns comprising Blue Sepharose, Phenyl Sepharose and hydroxylapatite, and the purity is checked by SDS-PAGE. [Svoboda et al. Anal Biochem 159 402 1986, Biochemistry 21 5516 1982, Biochem J 83 295 1978.]
PERTUSSIS TOXIN Preparation Products And Raw materials
Tag:PERTUSSIS TOXIN(70323-44-3) Related Product Information
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