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CALYCULIN A

CALYCULIN A structure

CAS No.: 101932-71-2

Chemical Name:: CALYCULIN A

Synonyms: C05370;CALYCULIN A;(-)-CALYCULIN A;Calyculin A ((-)-Calyculin A);CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;Calyculin A, protein phosphatase inhibitor;Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

CBNumber:: CB8233130

Molecular Formula:: C50H81N4O15P

Molecular Weight:: 1009.17

MDL Number:: MFCD06795864

MOL File:: 101932-71-2.mol

Last updated:2025-01-27 09:38:02

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CALYCULIN A Properties

Melting point	247-249°
alpha	D -60° (c = 0.1 in ethanol)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
pka	1.81±0.10(Predicted)
form	solid
color	white
optical activity	+59.815 (Ethanol)
biological source	sea sponge (Discodermia calyx)
Water Solubility	Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
Merck	13,1731
BRN	4903216
FDA UNII	7D07U14TK3
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301+H311+H331-H315

Precautionary statements

P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311

Hazard Codes

Risk Statements

23/24/25-38

Safety Statements

36/37/39-45

RIDADR

UN 3462 6.1/PG 3

WGK Germany

8-10

HazardClass

6.1(a)

PackingGroup

HS Code

2934999090

NFPA 704

	0
4		0

CALYCULIN A price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C5552	Calyculin A from Discodermia calyx ≥90% (HPLC), solid	101932-71-2	10μg	$221	2024-03-01	Buy
Sigma-Aldrich	5.08226	InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem	101932-71-2	5μg	$126	2024-03-01	Buy
Sigma-Aldrich	21279	Calyculin A from Discodermia calyx ≥90% (HPLC)	101932-71-2	10μg	$307	2024-03-01	Buy
Sigma-Aldrich	208851	Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC?? = 0.5-1 nM) and protein phosphatase 1 (PP1; IC?? = 2 nM).	101932-71-2	10μg	$216	2024-03-01	Buy
Alfa Aesar	J61952	Calyculin A, 98+%	101932-71-2	100microg	$531	2021-12-16	Buy

Product number	Packaging	Price	Buy
C5552	10μg	$221	Buy
5.08226	5μg	$126	Buy
21279	10μg	$307	Buy
208851	10μg	$216	Buy
J61952	100microg	$531	Buy

CALYCULIN A Chemical Properties,Uses,Production

Uses

Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.

Uses

Calyculin A from Discodermia calyx has been used:

as an inhibitor of serine-threonine protein phosphatase 2A
as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

Uses

Inhibitor of phosphatases 1 and 2a.

General Description

Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Biochem/physiol Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

storage

Store at -20°C

CALYCULIN A Preparation Products And Raw materials

Raw materials

Preparation Products

CALYCULIN A Suppliers

Global( 117)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30236	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky (shanghai) International Co.,Ltd	60
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58

View Lastest Price from CALYCULIN A manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-14	Calyculin A 101932-71-2	US $498.00 / μg		98%	10g	TargetMol Chemicals Inc.
	2024-11-13	Calyculin A 101932-71-2	US $498.00 / μg		98%	10g	TargetMol Chemicals Inc.

Calyculin A
101932-71-2
US $498.00 / μg
98%
TargetMol Chemicals Inc.

Calyculin A
101932-71-2
US $498.00 / μg
98%
TargetMol Chemicals Inc.

101932-71-2(CALYCULIN A)Related Search:

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Calyculin A (Serine/Threonine Phosphatase Inhibitor) Methyl-2-deoxy-alpha-D-ribofuranoside CALYCULIN A

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C05370 N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide CALYCULIN A, DISCODERMIA CALYX calyculin A from discodermia calyx CALYCULIN A FROM DISCODERMIA CALYX, 10 U G N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o L-Ribonamide, N-(3S)-3-4-(1E)-3-(2R,3R,5R,7S,8S,9R)-2-(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro4.5dec-7-yl-1-propenyl-2-oxa CALYCULIN A (-)-CALYCULIN A Calyculin A ((-)-Calyculin A) InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem L-Ribonamide, N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimet... Calyculin A, protein phosphatase inhibitor 101932-71-2 C50H81N4O15P Cell Biology Cell Signaling and Neuroscience BioChemical Protein Phosphatase 1 (PP1) Serine/Threonine Phosphatase Substrates Serine/Threonine Phosphatase Inhibitors Kinase/Phosphatase Biology Kinase/Phosphatase Biology Serine/Threonine Kinase Biology Protein phosphatase-1, Catalytic SubunitCancer Research Tumor Promotors Cell Signaling and Neuroscience P to Phosphatase InhibitorsSerine/Threonine Kinase Biology Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme Serine/Threonine Phosphatase Inhibitors Tumor Growth Regulation Inhibitor Serine/Threonine Phosphatase Substrates