1-(4-BROMOBENZYL)INDOLE-2,3-DIONE
- CAS No.
- 79183-37-2
- Chemical Name:
- 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE
- Synonyms
- VU0119498;VU0119498, 10 mM in DMSO;1-(4-BROMOBENZYL)INDOLE-2,3-DIONE;1-(4-bromobenzyl)-1H-indole-2,3-dione;1-[(4-Bromophenyl)methyl]indole-2,3-dione;1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]-;VU0119498, M1 muscarinic receptor agonist and pan mAChR M3, M5 PAM;antidiabetic,VU 0119498,Inhibitor,VU0119498,inhibit,VU-0119498,mAChR,pan,Muscarinic acetylcholine receptor
- CBNumber:
- CB82463915
- Molecular Formula:
- C15H10BrNO2
- Molecular Weight:
- 316.15
- MDL Number:
- MFCD01538528
- MOL File:
- 79183-37-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | |||||||||
| NFPA 704 |
|
1-(4-BROMOBENZYL)INDOLE-2,3-DIONE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0064669 | VU0119498 | 79183-37-2 | 10mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-0064669 | VU0119498 | 79183-37-2 | 50mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 5425CJ | 1-[(4-Bromophenyl)methyl]indole-2,3-dione | 79183-37-2 | 250mg | $203 | 2021-12-16 | Buy |
| ChemScene | CS-0064669 | VU0119498 | 79183-37-2 | 25mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0064669 | VU0119498 | 79183-37-2 | 100mg | $240 | 2021-12-16 | Buy |
1-(4-BROMOBENZYL)INDOLE-2,3-DIONE Chemical Properties,Uses,Production
Uses
VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 μM, respectively. VU0119498 has antidiabetic activity[1][2][3].
in vivo
VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion[3].
VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice[3].
| Animal Model: | Male WT mice (12 weeks)[3] |
| Dosage: | 0.1, 0.5, 2 mg/kg |
| Administration: | A single i.p. |
| Result: | Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg. Significantly augmented GSIS at the dose of 0.5 mg/kg. |
References
[1] Bridges TM, et, al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8. DOI:10.1021/jm900286j
[2] Bridges TM, et, al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. DOI:10.1016/j.bmcl.2010.01.109
[3] Zhu L, et, al. Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. DOI:10.1073/pnas.1904943116
1-(4-BROMOBENZYL)INDOLE-2,3-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-BROMOBENZYL)INDOLE-2,3-DIONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9888 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
