VU0238441
- CAS No.
- 85511-68-8
- Chemical Name:
- VU0238441
- Synonyms
- VU0238441;VU0238441, 10 mM in DMSO;7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione;7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-2,3-dione;7-Chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indole-2,3-dione;1H-Indole-2,3-dione, 7-chloro-1-[[4-(trifluoroMethyl)phenyl]Methyl]-;mAChR,Inhibitor,VU-0238441,VU0238441,Muscarinic acetylcholine receptor,VU 0238441,inhibit
- CBNumber:
- CB62628523
- Molecular Formula:
- C16H9ClF3NO2
- Molecular Weight:
- 339.7
- MDL Number:
- MFCD18642601
- MOL File:
- 85511-68-8.mol
- MSDS File:
- SDS
VU0238441 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0003123 | VU0238441 ≥97.0% | 85511-68-8 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-0003123 | VU0238441 ≥97.0% | 85511-68-8 | 10mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-0003123 | VU0238441 ≥97.0% | 85511-68-8 | 25mg | $130 | 2021-12-16 | Buy |
| ChemScene | CS-0003123 | VU0238441 ≥97.0% | 85511-68-8 | 50mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0003123 | VU0238441 ≥97.0% | 85511-68-8 | 100mg | $250 | 2021-12-16 | Buy |
VU0238441 Chemical Properties,Uses,Production
Uses
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].
Biological Activity
VU0238441 is a positive allosteric modulator (PAM) of pan-muscarinic acetylcholine receptor (mAChR) with EC50 values of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > for M5, M3, M2, M1 and M4, respectively 10 μM.
in vitro
VU0238441 is an analogue of VU0119498.
target
| Target | Value |
| mAChR M5 (Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 2.1 μM|
| mAChR M3 (Cell-free assay) | 2.2 μM |
| mAChR M2 (Cell-free assay) | 2.8 μM |
| mAChR M1 (Cell-free assay) | 3.2 μM |
| mAChR M4 (Cell-free assay) | >10 μM |
References
[1] Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. DOI:10.1016/j.bmcl.2009.11.089
[2] Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8. DOI:10.1021/jm900286j
VU0238441 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0238441 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6187 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
