ChemicalBook >> CAS DataBase List >>Nsc66811
Nsc66811
- CAS No.
- 6964-62-1
- Chemical Name:
- Nsc66811
- Synonyms
- Nsc66811;NSC 66811; NSC66811; NSC-66811;7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol;7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol;2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol;2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol;8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-;8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
- CBNumber:
- CB82498106
- Molecular Formula:
- C23H20N2O
- Molecular Weight:
- 340.42
- MDL Number:
- MFCD08823776
- MOL File:
- 6964-62-1.mol
Last updated:2023-09-20 16:43:00
| Melting point | 143.0 to 147.0 °C |
|---|---|
| Boiling point | 529.5±45.0 °C(Predicted) |
| Density | 1.235±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | solid |
| pka | 4.42±0.50(Predicted) |
| color | White |
| λmax | 250nm(EtOH)(lit.) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933.49.7000 |
Nsc66811 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444144 | MDM2 Antagonist II, NSC 66811 The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2. | 6964-62-1 | 10MG | $219 | 2023-06-20 | Buy |
| TCI Chemical | M2390 | 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol >98.0%(GC) | 6964-62-1 | 25mg | $77 | 2024-03-01 | Buy |
| TCI Chemical | M2390 | 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol >98.0%(GC) | 6964-62-1 | 100mg | $191 | 2024-03-01 | Buy |
| Cayman Chemical | 16431 | NSC 66811 ≥95% | 6964-62-1 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16431 | NSC 66811 ≥95% | 6964-62-1 | 5mg | $108 | 2024-03-01 | Buy |
Nsc66811 Chemical Properties,Uses,Production
Description
NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
Uses
NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells.
References
1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759
Nsc66811 Preparation Products And Raw materials
Raw materials
Preparation Products
Nsc66811 Suppliers
Global( 107)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24539 | 81 |
| Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |
| Wuhan Luohua Medical Technology Co.,Ltd. | 13477084141; 13477084141 | sales@luohuapharm.com | China | 469 | 60 |
6964-62-1(Nsc66811)Related Search:
Nsc66811
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol
8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-
NSC 66811; NSC66811; NSC-66811
8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol
2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol
6964-62-1