ARRY-424704, ARRY-704
- CAS No.
- 869357-68-6
- Chemical Name:
- ARRY-424704, ARRY-704
- Synonyms
- CS-396;ARRY704;AZD8330;ARRY-704;ARRY424704;ARRY-424704;AZD8330 (ARRY704;AZD8330 AZD-8330;AZD8330(ARRY-424704;ARRY-424704, ARRY-704
- CBNumber:
- CB82512518
- Molecular Formula:
- C16H17FIN3O4
- Molecular Weight:
- 461.23
- MDL Number:
- MFCD18384989
- MOL File:
- 869357-68-6.mol
| Density | 1.732 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH |
| form | solid |
| pka | 14.31±0.10(Predicted) |
| color | Off-white to pink |
| FDA UNII | G4990BOZ66 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H372-H301 | |||||||||
| Precautionary statements | P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
ARRY-424704, ARRY-704 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 5mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 10mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 50mg | $1041 | 2024-03-01 | Buy |
| Usbiological | 474069 | AZD 8330 | 869357-68-6 | 100mg | $2229 | 2021-12-16 | Buy |
ARRY-424704, ARRY-704 Chemical Properties,Uses,Production
Description
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
Uses
AZD8330 is an orally active and selective MEK inhibitor.
Definition
ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
in vivo
In tumour xenograft models, AZD8330 demonstrates dose-dependent tumour growth inhibition of approximately 90% at tolerated doses (1.0 mg/kg once daily [OD])[1].
target
ERK phosphorylation
IC 50
MEK1: 7 nM (IC50); MEK2: 7 nM (IC50)
References
1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.
ARRY-424704, ARRY-704 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7859 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from ARRY-424704, ARRY-704 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-17 | ARRY-424704, ARRY-704
869357-68-6
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | ARRY-424704, ARRY-704
869357-68-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-11-19 | AZD8330
869357-68-6
|
US $32.00-123.00 / mg | 98.72% | 10g | TargetMol Chemicals Inc. |
-
- ARRY-424704, ARRY-704
869357-68-6
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- ARRY-424704, ARRY-704
869357-68-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- AZD8330
869357-68-6
- US $32.00-123.00 / mg
- 98.72%
- TargetMol Chemicals Inc.
869357-68-6(ARRY-424704, ARRY-704)Related Search:
1of4