LY-2484595
- CAS No.
- 1186486-62-3
- Chemical Name:
- LY-2484595
- Synonyms
- SW-86;CS-653;SWF-86;LY-2484595;Evacetrapib;Evacetrapib, >=98%;LY-2484595 USP/EP/BP;LY-2484595 Evacetrapib;Evacetrapib (LY2484595);LY2484595; LY 2484595; LY-2484595
- CBNumber:
- CB82516031
- Molecular Formula:
- C31H36F6N6O2
- Molecular Weight:
- 638.65
- MDL Number:
- MOL File:
- 1186486-62-3.mol
Boiling point | 680.1±65.0 °C(Predicted) |
---|---|
Density | 1.40 |
storage temp. | Store at -20°C |
solubility | ≥32.1 mg/mL in DMSO; insoluble in H2O; ≥50.4 mg/mL in EtOH with ultrasonic |
pka | 4.73±0.10(Predicted) |
form | solid |
color | White to light yellow |
FDA UNII | 51XWV9K850 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08,GHS09 |
---|---|
Signal word | Danger |
Hazard statements | H410-H361-H400 |
Precautionary statements | P273-P391-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501 |
LY-2484595 price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23670 | Evacetrapib ≥98% | 1186486-62-3 | 5mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 23670 | Evacetrapib ≥98% | 1186486-62-3 | 10mg | $152 | 2024-03-01 | Buy |
Cayman Chemical | 23670 | Evacetrapib ≥98% | 1186486-62-3 | 50mg | $475 | 2024-03-01 | Buy |
Cayman Chemical | 23670 | Evacetrapib ≥98% | 1186486-62-3 | 100mg | $790 | 2024-03-01 | Buy |
TRC | E945200 | Evacetrapib | 1186486-62-3 | 25mg | $250 | 2021-12-16 | Buy |
LY-2484595 Chemical Properties,Uses,Production
Uses
Evacetrapib is an inhibitor of?cholesteryl ester transfer protein (CETP). CETP catalyzes the exchange of cholesteryl ester and triglyceride between lipoproteins and modulates HDL cholesterol levels in plasma. CETP inhibitors are potential compounds for treating coronary artery disease.
Definition
ChEBI: Evacetrapib is a benzazepine.
Biological Activity
evacetrapib is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) with ic50 value of 5.5nm [1].as a benzazepine-based inhibitor of cetp, evacetrapib is developed to increase hdl cholesterol for the treatment of coronary artery disease. evacetrapib is efficacious both in vitro and in vivo. the ic50 values of evacetrapib against cetp are 5.5nm and 26nm, respectively in the buffer assay using human recombinant cetp and in the plasma assay using human plasma cetp. in the animal model of human cetp/apoai double transgenic mouse line, oral administration of evacetrapib at 30mg/kg significantly inhibits the cetp activity as well as increases the level of hdl. besides that, the ed50 value of evacetrapib is less than 5mg/kg. compared to the previous inhibitors of cetp, evacetrapib has less side effects. it is found no to increase blood pressure zucker diabetic fatty rats and not to induce aldosterone or cortisol synthesis in h295r cells [1].
target
CETP
References
[1] cao g, beyer tp, zhang y, schmidt rj, chen yq, cockerham sl, zimmerman km, karathanasis sk, cannady ea, fields t, mantlo nb. evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates hdl cholesterol without inducing aldosterone or increasing blood pressure. j lipid res. 2011 dec;52(12):2169-76.
LY-2484595 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23430 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
View Lastest Price from LY-2484595 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-03 | LY-2484595
1186486-62-3
|
US $1.00-2.00 / KG | 1KG | 95.0-99.8% | 1KG;5KG 10KG; 100KG | Career Henan Chemical Co |
- LY-2484595
1186486-62-3
- US $1.00-2.00 / KG
- 95.0-99.8%
- Career Henan Chemical Co
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