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2,5-Di-tert-butylhydroquinone

2,5-Di-tert-butylhydroquinone structure

CAS No.: 88-58-4

Chemical Name:: 2,5-Di-tert-butylhydroquinone

Synonyms: BHQ;dtbhq;DBHQ;Probes;ANTIOXIDANT DTBHQ;Dibutylhydroquinone;Black Hole Quencher;2,5-ditertiary butyl hydroquinone;2,5-DI-TERT-BUTYL-1,4-HYDROQUINONE;2-carbamoyl-2-propylpentanoic acid

CBNumber:: CB8258782

Molecular Formula:: C14H22O2

Molecular Weight:: 222.32

MDL Number:: MFCD00008825

MOL File:: 88-58-4.mol

MSDS File:: SDS

Last updated:2024-12-18 14:08:57

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2,5-Di-tert-butylhydroquinone Properties

Melting point	216-218 °C(lit.)
Boiling point	321°C
Density	1,07 g/cm³
refractive index	1.4576 (estimate)
Flash point	216 °C
storage temp.	Store below +30°C.
solubility	almost transparency in Methanol
pka	11.89±0.23(Predicted)
form	Crystalline Powder
color	Light beige to pink-beige
Water Solubility	3.8mg/L at 20℃
BRN	2049542
Stability	Stable. Incompatible with oxidizing agents.
LogP	274 at 30℃
CAS DataBase Reference	88-58-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances	2,5-DI-TERT-BUTYLHYDROQUINONE
FDA 21 CFR	175.105; 176.170; 176.180; 177.2260; 177.2800
EWG's Food Scores	1
FDA UNII	26XK13B61B
NIST Chemistry Reference	1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-(88-58-4)
EPA Substance Registry System	1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)- (88-58-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H301-H317-H335-H410

Precautionary statements

P261-P264-P273-P280-P301+P310-P302+P352

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-24/25

WGK Germany

RTECS

MX5160000

Autoignition Temperature

790 °F

Hazard Note

Irritant

TSCA

Yes

HS Code

29072900

NFPA 704

	1
1		0

2,5-Di-tert-butylhydroquinone price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.21762	2,5-Di-tert-butylhydroquinone for synthesis	88-58-4	250g	$48	2024-03-01	Buy
Sigma-Aldrich	8.21762	2,5-Di-tert-butylhydroquinone for synthesis	88-58-4	1kg	$173	2024-03-01	Buy
Sigma-Aldrich	8.21762	2,5-Di-tert-butylhydroquinone for synthesis	88-58-4	25kg	$1520	2024-03-01	Buy
Sigma-Aldrich	112976	2,5-Di-tert-butylhydroquinone 99%	88-58-4	25g	$33.7	2024-03-01	Buy
Sigma-Aldrich	112976	2,5-Di-tert-butylhydroquinone 99%	88-58-4	1kg	$173	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.21762	250g	$48	Buy
8.21762	1kg	$173	Buy
8.21762	25kg	$1520	Buy
112976	25g	$33.7	Buy
112976	1kg	$173	Buy

2,5-Di-tert-butylhydroquinone Chemical Properties,Uses,Production

Description

2,5-Di-tert-butylhydroquinone, also known as 2,5-TBHQ or DTBHQ, belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety. It is a phenol derivative containing 2 phenol groups and 2 alkyl groups, each consisting of three methyl groups.

Chemical Properties

cream or pale brown solid

Uses

2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts.

Definition

ChEBI: A member of the class of hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5.

General Description

Mobilizes Ca²⁺ specifically from the Ins(1,4,5)P₃-sensitive Ca²⁺ stores by inhibiting microsomal and sarcoplasmic reticulum Ca²⁺-ATPase activity. Does not affect mitochondrial Ca²⁺ fluxes or plasma membrane Ca²⁺/Mg²⁺ ATPase activity. Useful for the study of endomembrane Ca²⁺ stores and plasma membrane Ca²⁺ permeability pathways.

Biological Activity

A selective inhibitor of endoplasmic reticulum Ca 2+ -ATPase.

Biochem/physiol Actions

2,5-Di-tert-butylhydroquinone specifically inhibits the sarcoplasmic reticulum (SR) Ca2+ uptake in the rat ventricle.

Purification Methods

Crystallise the hydroquinone from *C6H6 or AcOH. [Beilstein 6 III 4741.]

References

[1]. hasséssian h, vaca l, kunze dl. blockade of the inward rectifier potassium current by the ca(2+)-atpase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (bhq). br j pharmacol, 1994, 112(4): 1118-1122.
[2]. fusi f, gorelli b, valoti m, et al. effects of 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) on rat aorta smooth muscle. eur j pharmacol, 1998, 346(2-3): 237-243.
[3]. fusi f, saponara s, gagov h, et al. 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) inhibits vascular l-type ca(2+) channel via superoxide anion generation. br j pharmacol, 2001, 133(7): 988-996.
[4]. jan cr, ho cm, wu sn, et al. mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced ca2+ signals in madin darby canine kidney cells. eur j pharmacol, 1999, 365(1): 111-117.

2,5-Di-tert-butylhydroquinone synthesis

Synthesis of 2,5-Di-tert-butylhydroquinone from Hydroquinone and tert-Butanol

2,5-Di-tert-butylhydroquinone Preparation Products And Raw materials

Raw materials

Isobutylene Hydroquinone 1,4-Benzenediol, 2-(1,1-dimethylethyl)-5-(2-propen-1-yl)- 2,5-Di-tert-butyl-1,4-benzoquinone Allyltributyltin

Preparation Products

tert-Butylhydroquinone 6-Bromoindole-2-carboxylic acid (6-BROMO-1H-INDOL-2-YL)METHANOL 6-BROMO-1H-INDOLE-2-CARBALDEHYDE Ethyl 6-bromoindole-2-carboxylate

2,6-di-tert-butylhydroquinone Phenyl-t-butylether 1,4-Di-t-butyl-2,5-bis(2-methoxyethoxy)benzene, 99+% Redox shuttle ANL-RS2

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2,5-Di-tert-butylhydroquinone Suppliers

Global( 452)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12833	58
Shandong Juchuang Chemical Co., LTD	+undefined15030412209	admin@juchuangchem.com	China	387	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29793	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9004	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2986	55
Tianjin Zhongxin Chemtech Co., Ltd.	+86-022-66880623 +8618622897568	sales@tjzxchem.com	China	567	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Shandong Juchuang Chemical Co., LTD	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Hefei TNJ Chemical Industry Co.,Ltd.	55
Tianjin Zhongxin Chemtech Co., Ltd.	58
career henan chemical co	58

View Lastest Price from 2,5-Di-tert-butylhydroquinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-01-03	2 5-di-tert-butylhydroquinone 88-58-4	US $70.00 / kg	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-03-13	2 5-di-tert-butylhydroquinone 88-58-4	US $110.00-82.00 / kg	500kg	99.9	200tons	Shandong Juchuang Chemical Co., LTD
2023-08-26	2,5-Di-tert-butylhydroquinone 88-58-4	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

2 5-di-tert-butylhydroquinone
88-58-4
US $70.00 / kg
99
Hebei Zhuanglai Chemical Trading Co.,Ltd

2 5-di-tert-butylhydroquinone
88-58-4
US $110.00-82.00 / kg
99.9
Shandong Juchuang Chemical Co., LTD

2,5-Di-tert-butylhydroquinone
88-58-4
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2,5-Di-tert-butylhydroquinone Spectrum

2,5-Di-tert-butylhydroquinone(88-58-4)MS 2,5-Di-tert-butylhydroquinone(88-58-4)¹HNMR 2,5-Di-tert-butylhydroquinone(88-58-4)¹³CNMR 2,5-Di-tert-butylhydroquinone(88-58-4)IR1 2,5-Di-tert-butylhydroquinone(88-58-4)Raman

88-58-4(2,5-Di-tert-butylhydroquinone)Related Search:

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Cyhalofop-butyl Butyl acetate DI-TERT-BUTYL ETHER 2,5-Bis(1,1,3,3-tetramethylbutyl)hydroquinone 2,5-Di(tert-amyl)hydroquinone

2,6-di-tert-butylhydroquinone ALPHA-[[[2,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENOXY]CARBONYL]OXY]-2-NITRO-BENZENEACETIC ACID 2,5-DI-TERT-BUTYL-4-HYDROXYANISOLE

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DI-TERT-BUTYL HYDROQUINONE(2,5-) DI-T-BUTYLHYDROQUINONE 2,5-Di-tert-butylquinol Di-Tertiary Butylhydroquinone DTBHQ (DI-TERTIARY BUTYL 4-Benzenediol,2,5-bis(1,1-dimethylethyl)-1 antagedbh dibug naugard451 nocracns7 NS-7 santovaro 2,5 Di-tert-butyldroquinone 2,5-Di-tert-butyl-1,4-dihydroxybenzene 2,5-Bis(1,1-dimethylethyl)hydroquinone DI-TERT-BUTYLHYDROQUINONE 2,5-DI-TERT-BUTYL-HYDROQUINOL 2,5-DI(TERT-BUTYL)-1,4-BENZOHYDROQUINONE 2,5-Di-tert-butylhydroquinone, 98+% 2,5-Di-tert-butylhydroquinone,99% BHQ / DBHQ 2,5-DI-TERT-BUTYL HY 2,5-Bis(tert-butyl)benzene-1,4-diol 2,5-Bis(tert-butyl)hydroquinone 2,5-Di-tert-butylhydroquinone (DBHQ) 2,5-Di-tert-butylhydroquinone, 99% 1KG BUTYLHYDROQUINONE-TERT 1,4-DIHYDROXY-2,5-DI-TERT-BUTYLBENZENE T-BUTYLATED HYDROQUINONE TBUBHQ 2,5-BIS(2-METHYL-2-PROPYL)-1,4-BENZENEDIOL 2,5-DI(TERT-BUTYL)-1,4-BENZENEDIOL 2,5-DI-TERT-BUTYLHYDROQUINONE 2,5-DI-TERT-BUTYL HYDROXYQUINONE 2,5-DI-(T-BUTYL)-1,4-BENZOHYDROQUINONE 2,5-DI-(T-BUTYL)-1,4-HYDROQUINONE 2,5-DI-T-BUTYLHYDROQUINONE 2.5-Di-tert-bu BHQ Probes Custom qPCR Probes LNA probes locked nucleic acid qPCR assays qPCR designs Real-Time PCR Probes 1,4-Benzenediol,2,5-bis(1,1-dimethylethyl)- 2,5-bis(1,1-dimethylethyl)-4-benzenediol 2,5-di-tert-butylbenzene-1,4-diol 2,5-di-tert-butyl-hydroquinon 4-benzohydroquinone 5-di-t-butyl-1 Antioxygen DTBHQ (2,5-Di-tert-butylhydroquinone) BHQ - CAS 88-58-4 - Calbiochem di-tert-butyl hydroquinone(DTBHQ) 2,5-Di-tert-butylhydroquinone > 2,5-DI-TERT-BUTYLHYDROQUINONE FOR SYNTHE 2,5-Di-tert-butyL Butylhydroxyanisole Impurity 8