GAP 27
- CAS No.
- 198284-64-9
- Chemical Name:
- GAP 27
- Synonyms
- GAP 27;Gap 27(TFA);GAP 27, >98%;GAP-27; GAP27;SRPTEKTIFIIRPTEKTIFII;M.W. 1304.55 C60H101N15O17;Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%;Gap27,inhibit,Inhibitor,Gap-27,Gap 27,Gap Junction Protein
- CBNumber:
- CB8261625
- Molecular Formula:
- C60H101N15O17
- Molecular Weight:
- 1304.53
- MDL Number:
- MFCD11045577
- MOL File:
- 198284-64-9.mol
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
GAP 27 price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | G1794 | GAP 27 ≥97% (HPLC) | 198284-64-9 | 2mg | $179.6 | 2024-03-01 | Buy |
Alfa Aesar | J64109 | GAP 27 | 198284-64-9 | 0.5mg | $70.9 | 2023-06-20 | Buy |
Alfa Aesar | J64109 | GAP 27 | 198284-64-9 | 1mg | $110 | 2023-06-20 | Buy |
Tocris | 1476 | GAP 27 | 198284-64-9 | 1 | $259 | 2021-12-16 | Buy |
TRC | G245230 | GAP 27 | 198284-64-9 | 2.5mg | $385 | 2021-12-16 | Buy |
GAP 27 Chemical Properties,Uses,Production
Uses
Gap27 is a connexin (Cx) mimetic peptide that inhibits connexin-mediated communication (CMC). In vitro, Gap27 has been shown to improve cell migration during scrape-wound repair in hyperglycemia/hyperinsulinemia conditions. It also reduces acetylcholine-induced hyperpolarization in smooth muscle cells.
Biological Activity
gap 27 is a peptide(ser-arg-pro-thr-glu-lys-thr-ile-phe-ile-ile) derived from connexin 43 that is a selective gap junction blocker.connexins, or gap junctions, are a family of structurally-related transmembrane proteins. gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. this intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. this synthetic connexin-mimetic peptide, gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. it was concluded that gap-junctional communication is necessary for proper bone remodeling.figure1 formula of gap 27
storage
Store at -20°C
References
1. Berthoud, V. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 279, 619 (2000)2. Ilvesaro, J. et al. BMC Musculoskel. Disord. 2, 10 (2001)3. Chaytor, A. et al. Brit. J. Pharmacol. 144, 108 (2005)4. Boitano, S. and H. Evans Am. J. Physio.l Lung Cell Mol. Physiol. 279, L623 ( 2000).
GAP 27 Preparation Products And Raw materials
Raw materials
Preparation Products
GAP 27 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3581 | 58 |
Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |