ChemicalBook >> CAS DataBase List >>5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- structure

CAS No.: 919486-40-1

Chemical Name:: 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

Synonyms: CS-2440;AS 1517499;AS-1517499;AS 1517499;AS-1517499; AS1517499; AS 1517499;919486-40-1;STAT,AS-1517499,inhibit,AS 1517499,AS1517499,Inhibitor;4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide;5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

CBNumber:: CB82624615

Molecular Formula:: C20H20ClN5O2

Molecular Weight:: 397.86

MDL Number:: MFCD24038757

MOL File:: 919486-40-1.mol

MSDS File:: SDS

Last updated:2024-11-20 17:10:26

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5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- Properties

storage temp.	2-8°C
solubility	DMF: 25mg/mL; DMF:PBS (pH 7.2) (1:6): 0.14mg/mL; DMSO: 15mg/mL; Ethanol: 5mg/mL
form	powder
color	white to beige
InChI	InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
InChIKey	OZRMEKAUZBKTTC-UHFFFAOYSA-N
SMILES	C1(NCCC2=CC=C(O)C(Cl)=C2)=NC=C(C(N)=O)C(NCC2=CC=CC=C2)=N1
FDA UNII	2H31HOT08T

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1906	AS1517499 ≥98% (HPLC)	919486-40-1	5MG	$128	2023-06-20	Buy
Sigma-Aldrich	SML1906	AS1517499 ≥98% (HPLC)	919486-40-1	25MG	$517	2023-06-20	Buy
Cayman Chemical	29071	AS1517499	919486-40-1	5mg	$116	2024-03-01	Buy
Cayman Chemical	29071	AS1517499	919486-40-1	25mg	$381	2024-03-01	Buy
Cayman Chemical	29071	AS1517499	919486-40-1	1mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1906	5MG	$128	Buy
SML1906	25MG	$517	Buy
29071	5mg	$116	Buy
29071	25mg	$381	Buy
29071	1mg	$32	Buy

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- Chemical Properties,Uses,Production

Description

AS1517499 is a STAT6 inhibitor (IC₅₀ = 21 nM in a reporter assay). It inhibits IL-4-induced Th2 differentiation (IC₅₀ = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen T cells. AS1517499 (10 mg/kg) inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized mice when administered one hour prior to antigen exposure. It inhibits STAT6 phosphorylation and thyroid epithelial cell (TEC) hyperplasia and decreases serum levels of 3,3'',5-triiodo-L-thyronine (T3; ) and thyroxine (T4) in a mouse model of Graves'' disease when administered at a dose of 10 mg/kg per day. AS1517499 (20 mg/kg twice weekly) also inhibits tumor growth and liver metastasis in a murine orthotopic 4T1 mammary carcinoma model.

Biochem/physiol Actions

AS1517499 moderately inhibits the expression of RhoA (ras homolog family member A). Overexpression of RhoA protein is associated with allergic bronchial asthma.

storage

Store at -20°C

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- Suppliers

Global( 58)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14055	65
Wuhan TCASChem Technology Co., Ltd.	027-027-86697669 13986148687	sales@tcaschem.com	China	3889	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
BOC Sciences	65
Wuhan TCASChem Technology Co., Ltd.	55

View Lastest Price from 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	AS1517499 919486-40-1	US $34.00-80.00 / mg		98.7%	10g	TargetMol Chemicals Inc.

AS1517499
919486-40-1
US $34.00-80.00 / mg
98.7%
TargetMol Chemicals Inc.

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- AS 1517499 4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide AS-1517499;AS 1517499 AS-1517499; AS1517499; AS 1517499;919486-40-1 CS-2440 STAT,AS-1517499,inhibit,AS 1517499,AS1517499,Inhibitor 919486-40-1