Apricoxib
- CAS No.
- 197904-84-0
- Chemical Name:
- Apricoxib
- Synonyms
- TG 01;CS 706;R 109339;Apricoxib;Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-
- CBNumber:
- CB82627333
- Molecular Formula:
- C19H20N2O3S
- Molecular Weight:
- 356.44
- MDL Number:
- MFCD18633301
- MOL File:
- 197904-84-0.mol
Melting point | 148-151°C |
---|---|
Boiling point | 555.3±60.0 °C(Predicted) |
Density | 1.24±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 9.77±0.10(Predicted) |
color | Yellow |
FDA UNII | 5X5HB3VZ3Z |
NCI Drug Dictionary | apricoxib |
Apricoxib Chemical Properties,Uses,Production
Uses
Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.
Enzyme inhibitor
This oral COX-2 inhibitor (FW = 356.44 g/mol; CAS 162011-90-7), also named CS-706 and 4-[2- (4-ethoxyphenyl) -4-methyl-1H-pyrrol-1-yl]- benzene sulfonamide, targets Cyclooxygenase-2, which is over- expressed in advanced stage non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2). That said, a randomized, double-blind, placebo-controlled, multicenter phase II study found little evidence of efficacy of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected NSCLC. See also Rofecoxib
Apricoxib Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56077 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20035 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |