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(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran structure

CAS No.: 915095-89-5

Chemical Name:: (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran

Synonyms: (S)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran;915085-89-5;EMpagliflozin InterMediate;(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan;(3S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydro-furan;(S)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;Furan, 3-[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy]tetrahydro-, (3S)-;Empagliflozin-7;EMpagliflozin int3;Empagliflozin Intermediate2

CBNumber:: CB82652160

Molecular Formula:: C17H16BrClO2

Molecular Weight:: 367.66

MDL Number:: MFCD27920793

MOL File:: 915095-89-5.mol

MSDS File:: SDS

Last updated:2025-03-10 11:22:48

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(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Properties

Melting point	49-51°C
Boiling point	459.1±45.0 °C(Predicted)
Density	1.431±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1S/C17H16BrClO2/c18-14-3-6-17(19)13(10-14)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
InChIKey	HUNLNKBDQXGMAP-INIZCTEOSA-N
SMILES	O1CC[C@H](OC2=CC=C(CC3=CC(Br)=CC=C3Cl)C=C2)C1
FDA UNII	4WR8P4HZ8G

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
HS Code	2932190090

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B680755	(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran	915095-89-5	10g	$105	2021-12-16	Buy
Biosynth Carbosynth	IB75174	(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan	915095-89-5	5G	$110	2021-12-16	Buy
AK Scientific	J11711	EmpagliflozinImpurity7	915095-89-5	100mg	$148	2021-12-16	Buy
Ark Pharm	P000537154	(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 97%	915095-89-5	1g	$22	2021-12-16	Buy
Ark Pharm	P000537154	(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 97%	915095-89-5	5g	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
B680755	10g	$105	Buy
IB75174	5G	$110	Buy
J11711	100mg	$148	Buy
P000537154	1g	$22	Buy
P000537154	5g	$60	Buy

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Chemical Properties,Uses,Production

Description

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant to efficiently synthesize SGLT- 2 Epagliflozin inhibitors.

Physical Form

Solid

synthesis

To a mixture of AlCl3 (61.7 g, 0.463 mol) and (S)-(5-bromo-2-chlorophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone (100 g, 0.231 mol) in toluene (450 mL) was added 1,1,3,3-tetramethyldisiloxane (40.4 g, 0.301 mol) over 1 hour at<20 °C. The mixture was held at 20-23 °C for an additional 1.5 hours and cooled to 0-5 °C. The cooled solution was slowly added to ice-water (400 mL) over 15 min and the layers separated. The organic was treated with 3N NaOH (400 mL) at room temperature for 16-24 hours and the layers were separated. The organic was concentrated to a low volume (~130 mL). After diluted with acetonitrile (450 mL), the solution was again concentrated to a low volume (~130 mL). To the residue was added acetonitrile (400 mL) followed by a slow addition of water (200 mL). The resulting mixture was cooled to 0-3 °C and held for 2 hours. The solids were collected by filtration and dried in oven to give product. (S)-3-(4-(2-chloro-5- bromobenzyl)phenoxy)tetrahydrofuran (2a). 92% as white crystals.
synthesis of (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran

Uses

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant in the efficient synthesis of empagliflozin inhibitor of SGLT-2 utilizing AlCl3-promoted silane reduction of β-glycopyranoside.

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran synthesis

Synthesis of (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran from 5-Bromo-2-chlorobenzoic acid

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Preparation Products And Raw materials

Raw materials

(5-broMo-2-chlorophenyl)(4-hydroxyphenyl)Methanone (R)-(-)-3-Hydroxytetrahydrofuran 5-BROMO-2-CHLORO-BENZOYL CHLORIDE (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone

4-bromo-2-(bromomethyl)-1-chlorobenzene 4-(5-broMo-2-chlorobenzyl)phenol 5-Bromo-2-chlorobenzoic acid (S)-(+)-3-Hydroxytetrahydrofuran 4-Bromoaniline

Fluorobenzene p-Fluorotoluene

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Preparation Products

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Suppliers

Global( 393)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Chongqing Ensky Pharmaceutical Co.,Ltd.	+86-23-86815286 +86-13983794297	sales@ensky-chemical.com	China	92	58
Cangzhou Kangrui Pharma Tech Co. Ltd.,	+86-18632776803 +86-13833998158	cangzhoukangrui@126.com	China	739	58
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	212	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1015	58
Anhui Lianchuang Biological Medicine Co.,Ltd	+8613706129682	tiffany@langyupharm.com	China	86	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504 +86-17332992504	sales8@hbganmiao.com	China	300	58
Suzhou Nordica Biopharma CO.,LTD	+86-18136148818 +86-18567353071	3537297702@qq.com	China	299	58

Supplier	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Chongqing Ensky Pharmaceutical Co.,Ltd.	58
Cangzhou Kangrui Pharma Tech Co. Ltd.,	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
Anhui Lianchuang Biological Medicine Co.,Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
Suzhou Nordica Biopharma CO.,LTD	58

Synthesis and Application of (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran
(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is an important intermediate in the synthesis of Epagliflozi....
Aug 16，2022

View Lastest Price from (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-25	(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan 915095-89-5	US $0.00-0.00 / Kg/Drum	1KG	99%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-03-26	(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan 915095-89-5	US $0.00 / kg	1kg	98%	50kg	Shanghai Joiny Pharmaceutical Co.,LTD
2025-03-03	(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran 915095-89-5	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan
915095-89-5
US $0.00-0.00 / Kg/Drum
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan
915095-89-5
US $0.00 / kg
98%
Shanghai Joiny Pharmaceutical Co.,LTD

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran
915095-89-5
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

915095-89-5((3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran)Related Search:

2,3-Butanediol Empagliflozin (R)-Isomer Empagliflozin Impurity 23 Acetoxy Empagliflozin ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate

N/A Butanoic acid, 4-chloro-3-hydroxy-, (3S)- (S)-3-(4-benzylphenoxy)tetrahydrofuran (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin

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2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

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Empagliflozin Intermediate2 (3S)-3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]oxolane (3S)-3-(4-(5-bromo-2-chlorobenzyl) methyl]phenoxy]tetrahydro-furan (35)-3-[4-[(5-Bromo-2-chlorophenyl)methyllphenoxyltetrahydro-furan EMpagliflozin int3 Empagliflozin-7 Empagliflozin Bromo Impurity 3-[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy]tetrahydro- (3S)-3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]oxolane 915095-89-5 Empagliflozin impurity 10/Empagliflozin 5-Bromo Impurity/(S)-3-[4-(5-Bromo-2-chlorobenzyl)phenoxy]tetrahydrofuran 5-Bromo Empagliflozin Impurity (3S)-3-[4-[(5-BROMO-2-CHLOROPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN CAS NO 915095-89-5 Furan, 3-[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy]tetrahydro-, (3S)- ISO 9001：2015 REACH (3S)-3-[4-(5-bromo-2-chloro benzyl) phenoxy] tertahydrofuran 3-[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy]tetrahydro-furan Empa (S)-THF bromo compound (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro... (S)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene (S)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran EMpagliflozin InterMediate Furan, 3-[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy]tetrahydro-, (3S)- (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan 915085-89-5 (3S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydro-furan Empagliflozin Intermediate/ (3S)-3-[4-[(5-Bromo-2-Chlorophenyl)Methyl]Phenoxy]Tetrahydrofuran (3S)-3-[4-(5-Bromo-2-chlorobenzyI)phenoxy]tetrahydrofuran (3S)-3-[4-[(5-Bromo-2- chlorophenyl)methy1]phenoxy]tetrahydro-furan 3S-{4-[Benzyloxy-(5-bromo-2-chloro-phenyl)-methyl] -phenoxy}-tetrahydro-furan 915095-89-5 915085-89-5 C17H16BrClO2 Empagliflozin Intermediate 915095-89-5