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ChemicalBook CAS DataBase List (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran synthesis

5synthesis methods
21739-92-4 Synthesis
5-Bromo-2-chlorobenzoic acid

21739-92-4
635 suppliers
$8.00/10g

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / fluorobenzene / 2 h / 15 - 25 °C
2: aluminum (III) chloride / 1 h / 0 - 25 °C
3: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
4: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C

References:

Wang, Xiao-Jun;Zhang, Li;Byrne, Denis;Nummy, Larry;Weber, Dirk;Krishnamurthy, Dhileep;Yee, Nathan;Senanayake, Chris H. [Organic Letters,2014,vol. 16,# 16,p. 4090 - 4093]

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