ChemicalBook >> CAS DataBase List >>ICA-105574
ICA-105574
- CAS No.
- 316146-57-3
- Chemical Name:
- ICA-105574
- Synonyms
- ICA-105574;3-nitro-N-(4-phenoxyphenyl)-benzamide;Benzamide, 3-nitro-N-(4-phenoxyphenyl)-;activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel
- CBNumber:
- CB82750387
- Molecular Formula:
- C19H14N2O4
- Molecular Weight:
- 334.33
- MDL Number:
- MFCD01596399
- MOL File:
- 316146-57-3.mol
Last updated:2024-07-02 08:55:23
| Boiling point | 430.9±30.0 °C(Predicted) |
|---|---|
| Density | 1.333±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >20mg/mL |
| pka | 11.76±0.70(Predicted) |
| form | Solid |
| color | off-white to light tan |
| InChI | InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22) |
| InChIKey | GDWKBKTVROCPNZ-UHFFFAOYSA-N |
| SMILES | C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319-H400 |
| Precautionary statements | P273-P280-P305+P351+P338 |
| Hazard Codes | Xi,N |
| Risk Statements | 36-43-50/53 |
| Safety Statements | 26-36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
ICA-105574 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CBL0000327 | ICA-105574 95.00% | 316146-57-3 | 5MG | $684.81 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000327 | ICA-105574 95.00% | 316146-57-3 | 25MG | $977.48 | 2021-12-16 | Buy |
| DC Chemicals | DC22960 | ICA-105574 >98% | 316146-57-3 | 1g | $1800 | 2021-12-16 | Buy |
| DC Chemicals | DC22960 | ICA-105574 >98% | 316146-57-3 | 100mg | $450 | 2021-12-16 | Buy |
ICA-105574 Chemical Properties,Uses,Production
Description
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].
References
[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.
ICA-105574 Preparation Products And Raw materials
Raw materials
Preparation Products
ICA-105574 Suppliers
Global( 38)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8018 | 62 |
3-nitro-N-(4-phenoxyphenyl)-benzamide
ICA-105574
Benzamide, 3-nitro-N-(4-phenoxyphenyl)-
activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel
316146-57-3