CP21R7(CP21)
- CAS No.
- 125314-13-8
- Chemical Name:
- CP21R7(CP21)
- Synonyms
- CP21R7;CS-2352;CP21R7(CP21);CP21 (CP21R7);3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione;3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-
- CBNumber:
- CB83122439
- Molecular Formula:
- C19H15N3O2
- Molecular Weight:
- 317.34
- MDL Number:
- MFCD30343845
- MOL File:
- 125314-13-8.mol
| Boiling point | 627.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥14.25 mg/mL in DMSO |
| form | crystalline solid |
| pka | 7.79±0.60(Predicted) |
| color | Yellow to orange |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
CP21R7(CP21) price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20573 | CP21R7 ≥98% | 125314-13-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 20573 | CP21R7 ≥98% | 125314-13-8 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 20573 | CP21R7 ≥98% | 125314-13-8 | 10mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 20573 | CP21R7 ≥98% | 125314-13-8 | 25mg | $586 | 2024-03-01 | Buy |
| TRC | C781150 | CP21R7 | 125314-13-8 | 25mg | $825 | 2021-12-16 | Buy |
CP21R7(CP21) Chemical Properties,Uses,Production
Uses
CP21R7 is a potent and selective inhibitor of GSK3β.
Biological Activity
cp21r7 is a potent and selective inhibitor of gsk3β.the glycogen synthase kinase-3β (gsk-3β), a serine/threonine, is a ubiquitous kinase that participates in a multitude of cellular processes, such as cell membrane-to-nucleus signaling, gene transcription, translation, cytoskeletal structuring and cell cycle progression and survival [1].
in vitro
cp21r7 was an inhibitor of gsk3β and pkcα with the ic50 values of 1.8 and 1900 nm, respectively [1]. in the human reporter cell line, cp21r7 potently activated canonical wnt signallingeven at the dose of 1 μm, with highest activity seen at 3 μm [2]. in human ipscs exposed to n2b27 medium, supplemented with 1 μm gsk3β inhibitor cp21r7 strongly upregulated the expression of t (also known as brachyury, t/bry), a meso-endoderm marker expressed in the primitive streak [2].
References
[1] gong l, hirschfeld d, tan y c, et al. discovery of potent and bioavailable gsk-3β inhibitors[j]. bioorganic & medicinal chemistry letters, 2010, 20(5): 1693-1696.
[2] ciampi o, iacone r, longaretti l, et al. generation of functional podocytes from human induced pluripotent stem cells[j]. stem cell research, 2016, 17(1): 130-139.
CP21R7(CP21) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 973 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from CP21R7(CP21) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | CP21R7
125314-13-8
|
US $57.00-98.00 / mg | 98.21% | 10g | TargetMol Chemicals Inc. | ||
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2022-02-25 | CP21R7
125314-13-8
|
US $100.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | CP21R7
125314-13-8
|
US $100.00 / Kg/Bag | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |