ChemicalBook >> CAS DataBase List >>NS 1619
NS 1619
- CAS No.
- 153587-01-0
- Chemical Name:
- NS 1619
- Synonyms
- NS 161;NS 1619;NS1619;NS 1619;NS-1619, 10 mM in DMSO;NS 1619, KCa1.1 channel activator;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol;1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
- CBNumber:
- CB8359809
- Molecular Formula:
- C15H8F6N2O2
- Molecular Weight:
- 362.23
- MDL Number:
- MFCD00928190
- MOL File:
- 153587-01-0.mol
Last updated:2025-01-27 09:38:02
| Density | 1.563±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL |
| pka | 8.32±0.48(Predicted) |
| form | solid |
| color | white |
| Water Solubility |
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL ethanol: 26.6mg/mL 0.1 M NaOH: 5.2mg/mL DMSO: 5.3mg/mL H2O: insoluble |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
NS 1619 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N170 | NS 1619 powder | 153587-01-0 | 5mg | $180 | 2024-03-01 | Buy |
| Sigma-Aldrich | N170 | NS 1619 powder | 153587-01-0 | 25mg | $645 | 2024-03-01 | Buy |
| Cayman Chemical | 18876 | NS 1619 ≥98% | 153587-01-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18876 | NS 1619 ≥98% | 153587-01-0 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 18876 | NS 1619 ≥98% | 153587-01-0 | 10mg | $142 | 2024-03-01 | Buy |
NS 1619 Chemical Properties,Uses,Production
Uses
NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.
Definition
ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Biochem/physiol Actions
NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
storage
+4°C
NS 1619 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 104)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29809 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Henan Alfa Chemical Co., Ltd | China | 12003 | 58 | ||
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Alchem Pharmtech,Inc. | 58 |
| career henan chemical co | 58 |
| TargetMol Chemicals Inc. | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Henan Alfa Chemical Co., Ltd | 58 |
| InvivoChem | 58 |
| RR Scientific LLC | 58 |
| LEAP CHEM CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
153587-01-0(NS 1619)Related Search:
NS 1619
NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN
1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one
1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b
NS1619;NS 1619
NS 161
2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-
1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol
NS 1619, KCa1.1 channel activator
NS-1619, 10 mM in DMSO
153587-01-0
C15H8F6N2O2
Monovalent Ion Channels
Ion Channels
Voltage-gated Ion Channels
Potassium Channel Modulators
Cell Signaling and Neuroscience
Cell Biology
BioChemical
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