Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Structure
11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID structure
CAS No.
596104-94-8
Chemical Name:
11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID
Synonyms
CAY10410;CAY10410,CAY-10410;AFBJLDUEEOOVHL-WKELIDJCSA-N;11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID;9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2;9,10-DIHYDRO-15-DEOXY-DELTA12,14-PROSTAGLANDIN J2;Prosta-5,12,14-trien-1-oic acid, 11-oxo-, (5Z,12E,14Z)-
CBNumber:
CB8389954
Molecular Formula:
C20H30O3
Molecular Weight:
318.45
MDL Number:
MFCD03412003
MOL File:
Mol file
Last updated:2023-06-08 09:03:09
Request For Quotation

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Properties

storage temp. Store at -20°C
solubility DMF: 100 mg/ml; DMSO: 20 mg/ml; Ethanol: 75 mg/ml; PBS (7.2): 2.7 mg/ml

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18590 CAY10410 ≥98% (isomer mixture) 596104-94-8 500μg $87 2024-03-01 Buy
Cayman Chemical 18590 CAY10410 ≥98% (isomer mixture) 596104-94-8 1mg $163 2024-03-01 Buy
Cayman Chemical 18590 CAY10410 ≥98% (isomer mixture) 596104-94-8 5mg $680 2024-03-01 Buy
Cayman Chemical 18590 CAY10410 ≥98% (isomer mixture) 596104-94-8 10mg $1189 2024-03-01 Buy
Product number Packaging Price Buy
18590 500μg $87 Buy
18590 1mg $163 Buy
18590 5mg $680 Buy
18590 10mg $1189 Buy

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Chemical Properties,Uses,Production

Description

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.1 Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.2 CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.3

References

1. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83(5),803-812(1995).
2. Atsmon, J., Sweetman, B.J., Baertschi, S.W., et al. Formation of thiol conjugates of 9-deoxy-Δ9,Δ12(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2 Biochemistry 29,3760-3765(1990).
3. Shibata, T., Yamada, T., Ishii, T., et al. Thioredoxin as a molecular target of cyclopentenone prostaglandins J. Biol. Chem. 278(28),26046-26054(2003).

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4664 58
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
Nantong Feiyu Biological Technology CO.,LTD 0513-68819626; 13813788405 feiyubio2@163.com China 4821 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-400-8210725 4008210725 malulu@leyan.com China 40036 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Dalian Meilun Biotech Co., Ltd. 58
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
Nantong Feiyu Biological Technology CO.,LTD 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

596104-94-8(11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID)Related Search:

PROSTAGLANDIN J2
11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID 9,10-DIHYDRO-15-DEOXY-DELTA12,14-PROSTAGLANDIN J2 CAY10410 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2 AFBJLDUEEOOVHL-WKELIDJCSA-N Prosta-5,12,14-trien-1-oic acid, 11-oxo-, (5Z,12E,14Z)- CAY10410,CAY-10410 596104-94-8