Meisoindigo
- CAS No.
- 97207-47-1
- Chemical Name:
- Meisoindigo
- Synonyms
- CS-1454;Natura-α;Dian III;MEISOINDIGO;3'-digallate;Theaflavine-3;Meisoindigo, >96%;Methylisoindigotin;Meisoindigo, >=98%;Meisoindigo(Natura-
- CBNumber:
- CB8394558
- Molecular Formula:
- C17H12N2O2
- Molecular Weight:
- 276.29
- MDL Number:
- MFCD05988503
- MOL File:
- 97207-47-1.mol
| Melting point | 236-237°C |
|---|---|
| Boiling point | 482.0±45.0 °C(Predicted) |
| Density | 1.381±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic |
| form | powder to crystal |
| pka | 11.62±0.20(Predicted) |
| color | Orange to Brown to Dark red |
| FDA UNII | 92UIP6405R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933.79.1500 | |||||||||
| NFPA 704 |
|
Meisoindigo price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3082 | Meisoindigo >98.0%(HPLC) | 97207-47-1 | 25mg | $150 | 2024-03-01 | Buy |
| TCI Chemical | M3082 | Meisoindigo >98.0%(HPLC) | 97207-47-1 | 100mg | $410 | 2024-03-01 | Buy |
| Cayman Chemical | 18007 | Meisoindigo ≥95% | 97207-47-1 | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18007 | Meisoindigo ≥95% | 97207-47-1 | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 18007 | Meisoindigo ≥95% | 97207-47-1 | 5mg | $341 | 2024-03-01 | Buy |
Meisoindigo Chemical Properties,Uses,Production
Description
Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
Chemical Properties
mp 236-237°C
Uses
Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy
Uses
Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).
in vivo
Meisoindigo (Dian III; 50-150?mg/kg; IP; daily; for 14 days) has anti-leukemic activity in?vivo[1].
Meisoindigo (2, 4, 8, 12 mg/kg; IP; before MCAO and 2 h after reperfusion) significantly reduces infarct volume, ameliorates neurological deficits 3 days after middle cerebral artery occlusion (MCAO) in Wild-type C57BL/6J mice (25-30 g). Meisoindigo reduces edema and lowers AQP4 expression in the brain[2].
| Animal Model: | NOD/SCID mice, 6-8 weeks old, with HL-60 leukemic cells[1] |
| Dosage: | 50, 100, 150?mg/kg |
| Administration: | IP; daily; for 14 days |
| Result: | Had anti-leukemic activity in?vivo. |
References
[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.
Meisoindigo Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
View Lastest Price from Meisoindigo manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Meisoindigo
97207-47-1
|
US $64.00-178.00 / mg | 98.19% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | Meisoindigo USP/EP/BP
97207-47-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-04-30 | Meisoindigo
97207-47-1
|
US $0.00-0.00 / Kg | 1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd
|
-
- Meisoindigo
97207-47-1
- US $64.00-178.00 / mg
- 98.19%
- TargetMol Chemicals Inc.
-
- Meisoindigo USP/EP/BP
97207-47-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Meisoindigo
97207-47-1
- US $0.00-0.00 / Kg
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd