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GANAXOLONE

CAS No.
38398-32-2
Chemical Name:
GANAXOLONE
Synonyms
Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;Noradrenaline Impurity 69;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
CBNumber:
CB8498146
Molecular Formula:
C22H36O2
Molecular Weight:
332.52
MDL Number:
MFCD09971088
MOL File:
38398-32-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

GANAXOLONE Properties

Melting point 190-192°
alpha D +103°
Boiling point 434.8±18.0 °C(Predicted)
Density 1.036±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~4.2 mg/mL
form solid
pka 15.18±0.70(Predicted)
color white
FDA UNII 98WI44OHIQ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Safety Statements  22-24/25
WGK Germany  3
RTECS  TU4384700

GANAXOLONE price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G7795 Ganaxolone solid 38398-32-2 5mg $196 2024-03-01 Buy
Sigma-Aldrich G7795 Ganaxolone solid 38398-32-2 25mg $677 2024-03-01 Buy
Cayman Chemical 20919 Ganaxolone ≥98% 38398-32-2 1mg $32 2024-03-01 Buy
Cayman Chemical 20919 Ganaxolone ≥98% 38398-32-2 5mg $109 2024-03-01 Buy
Cayman Chemical 20919 Ganaxolone ≥98% 38398-32-2 10mg $153 2024-03-01 Buy
Product number Packaging Price Buy
G7795 5mg $196 Buy
G7795 25mg $677 Buy
20919 1mg $32 Buy
20919 5mg $109 Buy
20919 10mg $153 Buy

GANAXOLONE Chemical Properties,Uses,Production

Description

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

Uses

Treatment of epilepsy and migraine.

Uses

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

Definition

ChEBI: Ganaxolone is a corticosteroid hormone.

Biological Activity

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Biochem/physiol Actions

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

storage

+4°C

566-65-4
676-58-4
38398-32-2
Synthesis of GANAXOLONE from 5α-Pregnane-3,20-dione and Methylmagnesium chloride

GANAXOLONE Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
Hunan Yuanye Pharmaceutical Co., Ltd.
+8615857615745 2675013845@qq.com China 87 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Moxin Chemicals
+8617320513646 mike@molcoo.com China 9447 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Hunan Well Medicine Synthesis Technology Co., Ltd 13574065797 3877753494@qq.com China 33 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 261 61

View Lastest Price from GANAXOLONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GANAXOLONE pictures 2020-01-10 GANAXOLONE
38398-32-2
US $0.01 / KG 1KG 98%; 99% 500g;1kg; 25kg Career Henan Chemical Co
  • GANAXOLONE pictures
  • GANAXOLONE
    38398-32-2
  • US $0.01 / KG
  • 98%; 99%
  • Career Henan Chemical Co

38398-32-2(GANAXOLONE)Related Search:

3α-hydroxy-3β-methyl-5α-pregnan-20-one (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone (3α,5α)-3-Hydroxy-3-methylpregnan-20-one 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)- Fampridine Impurity 80 5α-PREGNAN-3β-METHYL-3α-OL-20-ONE 1-[(Chemicalbook3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone 3α-hydroxy-3β-methyl-5α-pregnan-20-one 5α-PREGNAN-3β-METHYL-3α- Noradrenaline Impurity 69 38398-32-2