SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT
- CAS No.
- 98672-91-4
- Chemical Name:
- SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT
- Synonyms
- BMS-18290;RJNDVCNWVBWHLY-BHQIHCQQSA-N;SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT;1S-[1α,2β(5Z),3β,4α]]-7-[3-[2-(Phenylcarbamoyl)hydrazinomethyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid;(Z)-7-[(1R,4S)-3α-[[2-[(Phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2α-yl]-5-heptenoic acid;1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoicacid;5-Heptenoic acid, 7-[(1S,2R,3R,4R)-3-[[2-[(phenylamino)carbonyl]hydrazinyl]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-, (5Z)-
- CBNumber:
- CB8504564
- Molecular Formula:
- C21H29N3O4
- Molecular Weight:
- 387.47
- MDL Number:
- MOL File:
- 98672-91-4.mol
| Melting point | 92-95 °C |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤0.9mg/ml in ethanol;5mg/ml in DMSO;0.14mg/ml in dimethyl formamide |
| form | White to off-white crystalline powder. |
| pka | 4.76±0.10(Predicted) |
| color | White to off-white |
SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19025 | SQ 29,548 ≥98% | 98672-91-4 | 1mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 19025 | SQ 29,548 ≥98% | 98672-91-4 | 5mg | $383 | 2024-03-01 | Buy |
| Cayman Chemical | 19025 | SQ 29,548 ≥98% | 98672-91-4 | 10mg | $680 | 2024-03-01 | Buy |
| TRC | S683703 | SQ-29548 | 98672-91-4 | 1mg | $1200 | 2021-12-16 | Buy |
| ApexBio Technology | C4237 | SQ29,548 | 98672-91-4 | 10mg | $720 | 2021-12-16 | Buy |
SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT Chemical Properties,Uses,Production
Description
SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM. It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 μM. It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM. SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF2α.
Uses
SQ-29548 is a potent and selective thromboxane A2 receptor antagonist.
in vitro
in guinea-pig trachea and rat aorta, sq 29,548 competitively antagonized the activity of 9,11-azo pgh2 with pa2 values of 7.8 and 8.4, respectively. sq 29,548 competitively antagonized contractions of guinea-pig tracheal spirals induced by 11,9-epoxymethano pgh2 with the pa2 value of 9.1. the sq 29,548 competitively antagonized tracheal induced by 11,9-epoxymethano pgh2 and pgd2 with the pa2 values of 8.2 and 8.3, respectively. sq 29,548 partially antagonized the contractions of guinea-pig tracheal spirals caused by pge2. sq 29,548 significantly inhibited the aorta contracting activity of 11,9-epoxymethano pgh2 (pa2 = 9.1) and thromboxane a2 released from perfused guinea-pig lungs upon arachidonic acid challenge [1].
in vivo
in anesthetized dogs, sq 29,548 (0.2 mg/kg/h) completely inhibited the vasoconstrictor response of the left circumflex coronary artery (lcx) caused by u-46619. sq 28,585 showed no effects on infarct size as compared with vehicle controls [3]. in sham mi rats, treatment with sq-29,548 significantly blunted this loss of ck activity and amino-nitrogen concentration from the ischemic myocardium. sq-29,548 significantly prevented the extension of ischemic damage in the myocardium and improved survival following acute coronary artery ligation [4].
References
[1] ogletree m l, harris d n, greenberg r, et al. pharmacological actions of sq 29,548, a novel selective thromboxane antagonist[j]. journal of pharmacology and experimental therapeutics, 1985, 234(2): 435-441.
[2] abe t, takeuchi k, takahashi n, et al. rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization[j]. journal of clinical investigation, 1995, 96(2): 657.
[3] grover g j, schumacher w a. effect of the thromboxane receptor antagonist sq 29,548 on myocardial infarct size in dogs[j]. journal of cardiovascular pharmacology, 1988, 11(1): 29-35.
[4] hock c e, brezinski m e, lefer a m. anti-ischemic actions of a new thromboxane receptor antagonist, sq-29,548, in acute myocardial ischemia[j]. european journal of pharmacology, 1986, 122(2): 213-219.
SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT Preparation Products And Raw materials
Raw materials
Preparation Products
SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | zhouzz@univ-bio.com | China | 24990 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |