SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT
동의어(영문):
BMS-18290;RJNDVCNWVBWHLY-BHQIHCQQSA-N;SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT;1S-[1α,2β(5Z),3β,4α]]-7-[3-[2-(Phenylcarbamoyl)hydrazinomethyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid;(Z)-7-[(1R,4S)-3α-[[2-[(Phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2α-yl]-5-heptenoic acid;1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoicacid;5-Heptenoic acid, 7-[(1S,2R,3R,4R)-3-[[2-[(phenylamino)carbonyl]hydrazinyl]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-, (5Z)-
≤0.9mg/ml in ethanol;5mg/ml in DMSO;0.14mg/ml in dimethyl formamide
물리적 상태
백색 내지 황백색의 결정성 분말.
산도 계수 (pKa)
4.76±0.10(Predicted)
색상
White to off-white
안전
SQ29,548(강력하고구체적인트롬복사NEA2수용체 C화학적 특성, 용도, 생산
개요
SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM. It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 μM. It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM. SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF2α.
용도
SQ-29548 is a potent and selective thromboxane A2 receptor antagonist.
