EURYCOMALACTONE(P)
- CAS No.
- 23062-24-0
- Chemical Name:
- EURYCOMALACTONE(P)
- Synonyms
- Eurycomalatone;Eurycomalactone;EURYCOMALACTONE(P);EURYCOMALACTONE(AS);EURYCOMALACTONE(SH);Eurycomalactone, 10 mM in DMSO;(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione;(1R,2R,5S,5aR,7aS,11S,11aS,11bR)-1,11-dihydroxy-5a,8,11a,12-tetramethyl-1,5,5a,7,7a,11,11a,11b-octahydro-2,5-methanonaphtho[1,2-d]oxepine-4,6,10(2H)-trione;DNA double-strand,Eurycomalactone,NF-κB,protein synthesis,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,cisplatin,cyclin D1,inhibit,Eurycoma longifolia Jack;2,5-Methanonaphth[1,2-d]oxepin-4,6,10(2H)-trione, 1,5,5a,7,7a,11,11a,11b-octahydro-1,11-dihydroxy-5a,8,11a,12-tetramethyl-, (1R,2R,5S,5aR,7aS,11S,11aS,11bR,12R)-
- CBNumber:
- CB8506957
- Molecular Formula:
- C19H24O6
- Molecular Weight:
- 348.39
- MDL Number:
- MFCD32200280
- MOL File:
- 23062-24-0.mol
- MSDS File:
- SDS
EURYCOMALACTONE(P) price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 300261 | Eurycomalactone | 23062-24-0 | 5mg | $581 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259231 | Eurycomalactone 94% | 23062-24-0 | 10mg | $591.6 | 2021-12-16 | Buy |
| ChemScene | CS-0032756 | Eurycomalactone | 23062-24-0 | 1mg | $210 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259231 | Eurycomalactone 94% | 23062-24-0 | 5mg | $433.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0003247 | EURYCOMALACTONE 95.00% | 23062-24-0 | 5MG | $504.53 | 2021-12-16 | Buy |
EURYCOMALACTONE(P) Chemical Properties,Uses,Production
Uses
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].
Definition
ChEBI: Eurycomalactone is a steroid lactone.
References
[1] Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G?/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. DOI:10.3727/096504019X15736439848765
[2] Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. DOI:10.3892/or.2020.7710
[3] Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. DOI:10.1021/acs.jnatprod.7b00503
EURYCOMALACTONE(P) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Fortuna Chemical Co.,Ltd | +8618007136271 | hk@fortunachem.com | China | 5991 | 58 |
| Mensura Group Limited | +8618109034517 | 1058503172@qq.com | China | 2900 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 19240 | 64 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 021-61312847 13636370518 | shyysw007@163.com | China | 4999 | 60 |