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ERK1/2 inhibitor 1

ERK1/2 inhibitor 1 structure

CAS No.: 2095719-90-5

Chemical Name:: ERK1/2 inhibitor 1

Synonyms: ERK1/2 INHIBITOR 1;ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1;(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide;2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-

CBNumber:: CB85540361

Molecular Formula:: C29H32ClN5O4

Molecular Weight:: 550.06

MDL Number:: MFCD31813665

MOL File:: 2095719-90-5.mol

Last updated:2024-07-02 08:55:37

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ERK1/2 inhibitor 1 Properties

Density	1.344±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (454.50 mM; Need ultrasonic)
pka	13.73±0.46(Predicted)
form	Solid
color	Off-white to light yellow

ERK1/2 inhibitor 1 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0044721	ERK1/2inhibitor1 99.16%	2095719-90-5	5mg	$650	2021-12-16	Buy
ChemScene	CS-0044721	ERK1/2inhibitor1 99.16%	2095719-90-5	10mg	$980	2021-12-16	Buy
ChemScene	CS-0044721	ERK1/2inhibitor1 99.16%	2095719-90-5	50mg	$2550	2021-12-16	Buy
ChemScene	CS-0044721	ERK1/2inhibitor1 99.16%	2095719-90-5	100mg	$3550	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0044721	5mg	$650	Buy
CS-0044721	10mg	$980	Buy
CS-0044721	50mg	$2550	Buy
CS-0044721	100mg	$3550	Buy

ERK1/2 inhibitor 1 Chemical Properties,Uses,Production

Biological Activity

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

References

[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.

ERK1/2 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

ERK1/2 inhibitor 1 Suppliers

Global( 12)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Anyinuo Biomedical Technology Co., Ltd.	021-34625901	420970979@qq.com	China	5821	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10011	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5014	58
Shanghai Zunlijia Life Technology Co., Ltd	021-34045219 13195660927	huji@zunlijia.com	China	2303	58
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	hanfangpharma@126.com	China	30968	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Anyinuo Biomedical Technology Co., Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
cjbscvictory	58
TargetMol Chemicals Inc.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58
Shanghai Zunlijia Life Technology Co., Ltd	58
Nantong Hanfang Biotechnology Co. , Ltd.	58

ERK1/2 inhibitor 1 Spectrum

ERK1/2 inhibitor 1(2095719-90-5)¹HNMR

ERK1/2 INHIBITOR 1 2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)- ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1 (R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide 2095719-90-5 C29H32ClN5O4