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ChemicalBook >> CAS DataBase List >>4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-

4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-

4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Structure
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- structure
CAS No.
1695533-44-8
Chemical Name:
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
Synonyms
Erastin2;2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxy-[1,1'-biphenyl]-3-yl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-;4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
CBNumber:
CB85540826
Molecular Formula:
C36H35ClN4O4
Molecular Weight:
623.14
MDL Number:
MFCD32867306
MOL File:
1695533-44-8.mol
Last updated:2024-07-02 08:55:37
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4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Properties

Boiling point 807.0±75.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
storage temp. Store at -20°,Cprotect from light
solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.25 mg/ml; DMSO: 1 mg/ml
form A crystalline solid
pka 5.05±0.10(Predicted)
color White to off-white

4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27087 Erastin2 1695533-44-8 1mg $81 2024-03-01 Buy
Cayman Chemical 27087 4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- 1695533-44-8 10mg $396 2024-03-01 Buy
Cayman Chemical 27087 Erastin2 1695533-44-8 5mg $219 2024-03-01 Buy
Product number Packaging Price Buy
27087 1mg $81 Buy
27087 10mg $396 Buy
27087 5mg $219 Buy

4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Chemical Properties,Uses,Production

Description

Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.1,2 It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 μM).2 It induces cell death in HAP1 cells when used at a concentration of 5 μM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine .1 Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 μM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 μM).3 It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 μM.

References

1. Cao, J.Y., Poddar, A., Magtanong, L., et al. A genome-wide haploid genetic screen identifies regulators of glutathione abundance and ferroptosis sensitivity Cell Rep. 26(6),1544-1556(2019).
2. Dixon, S.J., Patel, D.N., Welsch, M., et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis Elife 3,e02523(2014).
3. Magtanong, L., Ko, P.-J., To, M., et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state Cell Chem. Biol. 26(3),420-432(2019).

4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Suppliers

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Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 289 58
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7295 58
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Aladdin Scientific 		58
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai meikai technology co., ltd 58
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Erastin2 2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxy-[1,1'-biphenyl]-3-yl)quinazolin-4(3H)-one 4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- 1695533-44-8 1