4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
![4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- price.](/CAS/20210111/GIF/1695533-44-8.gif)
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- $81 - $396
- Product name: 4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
- CAS: 1695533-44-8
- MF: C36H35ClN4O4
- MW: 623.14
- EINECS:
- MDL Number:MFCD32867306
- Synonyms:4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-;Erastin2;2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxy-[1,1'-biphenyl]-3-yl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
3 prices
Selected condition：
Brand
- Cayman Chemical
Package
- 1mg
- 5mg
- 10mg
- ManufacturerCayman Chemical
- Product number27087
- Product descriptionErastin2
- Packaging1mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27087
- Product descriptionErastin2
- Packaging5mg
- Price$219
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27087
- Product description4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
- Packaging10mg
- Price$396
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 27087 | Erastin2 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 27087 | Erastin2 | 5mg | $219 | 2024-03-01 | Buy |
| Cayman Chemical | 27087 | 4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- | 10mg | $396 | 2024-03-01 | Buy |
Properties
Boiling point :807.0±75.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :Store at -20°,Cprotect from light
solubility :DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.25 mg/ml; DMSO: 1 mg/ml
form :A crystalline solid
pka :5.05±0.10(Predicted)
color :White to off-white
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :Store at -20°,Cprotect from light
solubility :DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.25 mg/ml; DMSO: 1 mg/ml
form :A crystalline solid
pka :5.05±0.10(Predicted)
color :White to off-white
Safety Information
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Description
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.1,2 It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 μM).2 It induces cell death in HAP1 cells when used at a concentration of 5 μM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine .1 Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 μM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 μM).3 It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 μM.Suppliers and manufacturers
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