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3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) structure

CAS No.: 4322-58-1

Chemical Name:: 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Synonyms: -((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);3,3′-[(2-chlorophenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 3,3'-[(2-chlorophenyl)methylene]bis[4-hydroxy-

CBNumber:: CB86197889

Molecular Formula:: C25H15ClO6

Molecular Weight:: 446.84

MDL Number:

MOL File:: 4322-58-1.mol

Last updated:2023-05-21 10:59:17

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3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Properties

Melting point	198-199 °C
Boiling point	703.3±60.0 °C(Predicted)
Density	1.575±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
form	A crystalline solid
pka	4.20±1.00(Predicted)

3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	1708DM	COUMARIN,3,3'-(o-CHLOROBENZYLIDENE)BIS(4-HYDROXY-	4322-58-1	10mg	$394	2021-12-16	Buy

Product number	Packaging	Price	Buy
1708DM	10mg	$394	Buy

3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Chemical Properties,Uses,Production

Description

3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; K_i = 50 μM).^1,2 It also inhibits urease (IC₅₀ = 84.53 μM for the Jack bean enzyme).³

References

1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities Bioorg. Med. Chem. 14(23),8066-8072(2006).
2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1 Molecules 24(22),E4192(2019).
3. Khan, K.M., Iqbal, S., Lodhi, M.A., et al. Biscoumarin: New class of urease inhibitors; economical synthesis and activity Bioorg. Med. Chem. 12(8),1963-1968(2004).

3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Preparation Products And Raw materials

Raw materials

Preparation Products

3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11975	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19696	58

Supplier	Advantage
Shanghai Hongye Biotechnology Co. Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) -((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) 2H-1-Benzopyran-2-one, 3,3'-[(2-chlorophenyl)methylene]bis[4-hydroxy- 3,3′-[(2-chlorophenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one 3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) 4322-58-1