2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
- CAS No.
- 657408-07-6
- Chemical Name:
- 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
- Synonyms
- 98% SPhos;Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane;dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane;6´NS-PHOS;SPhos 97%;SPhos, >=98%;REF DUPL: S-PHOS;-diMethoxybiphenyl;S-Phos, ChemDose(TM) tablets
- CBNumber:
- CB8634850
- Molecular Formula:
- C26H35O2P
- Molecular Weight:
- 410.53
- MDL Number:
- MFCD05861611
- MOL File:
- 657408-07-6.mol
- MSDS File:
- SDS
Melting point | 164-166°C |
---|---|
Boiling point | 513.3±40.0 °C(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | soluble in Chloroform |
form | crystal |
color | white |
Sensitive | Air Sensitive |
InChIKey | VNFWTIYUKDMAOP-UHFFFAOYSA-N |
FDA UNII | XI1MQ32186 |
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl price More Price(55)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 901906 | SPhos 95% | 657408-07-6 | 1G | $31.44 | 2024-03-01 | Buy |
Sigma-Aldrich | 901906 | SPhos 95% | 657408-07-6 | 5G | $143 | 2024-03-01 | Buy |
Sigma-Aldrich | 901906 | SPhos 95% | 657408-07-6 | 25G | $270.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 932191 | SPhos ChemBeads | 657408-07-6 | 1g | $287 | 2024-03-01 | Buy |
Sigma-Aldrich | 901906 | SPhos 95% | 657408-07-6 | 250G | $736 | 2024-03-01 | Buy |
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Chemical Properties,Uses,Production
Uses
SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
Reactions
- Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
- Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
- Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
- Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
- Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
- Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
- Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
- Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids
- and esters.
![Reactions of 657408-07-6](/NewsImg/2018-01-18/20181181833459725.jpg)
Chemical Properties
White solid
Uses
suzuki reaction
Uses
S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.
General Description
SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
![694-80-4](/CAS/GIF/694-80-4.gif)
![151-10-0](/CAS/GIF/151-10-0.gif)
![16523-54-9](/CAS/GIF/16523-54-9.gif)
![657408-07-6](/CAS/GIF/657408-07-6.gif)
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
XINXIANG RUNYU MATERIAL CO., LTD. | +86-13592593621; +8613592593621 | sales@runvmat.com | China | 432 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5823 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-26 | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
657408-07-6
|
US $0.00 / Kg/Drum | 1KG | 99% | 200mt | Jinan Finer Chemical Co., Ltd | |
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2024-08-21 | SPHOS
657408-07-6
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
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2024-07-11 | SPhos
657408-07-6
|
US $1290.00 / Kg | 1Kg | 98 | 500 Kg | R&D Scientific Inc. |
-
- 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
657408-07-6
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- SPHOS
657408-07-6
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- SPhos
657408-07-6
- US $1290.00 / Kg
- 98
- R&D Scientific Inc.
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